Tag: 488.603

The clinical efficacy of pulmonary hypertension-specific agents in idiopathic pulmonary fibrosis: systematic review and meta-analysis of randomized controlled clinical trials was written by Lee, Jonghoo;Song, Jae-Uk. And the article was included in Journal of Korean Medical Science in 2020.Computed Properties of C23H32N6O4S This article mentions the following:

Pulmonary hypertension (PH) is common in patients with idiopathic pulmonary fibrosis (IPF) and is associated with poor outcomes. This study was performed to determine the clin. efficacy of PH-specific therapeutic agents for IPF patients. We performed a systematic review and meta-anal. using MEDLINE, EMBASE, and the Cochrane Central Register. We searched randomized controlled trials (RCTs) without language restriction until Nov. 2018. The primary outcome was all-cause mortality to end of study. We analyzed 10 RCTs involving 2,124 patients, 1,274 of whom received PH-specific agents. In pooled estimates, the use of PH-specific agents was not significantly associated with reduced all-cause mortality to end of study compared with controls (hazard ratio, 0.99; 95% confidence interval [CI], 0.92, 1.06; P = 0.71; I2 = 30%). When we performed subgroup analyses according to the type of PH-specific agent, sample size, age, forced vital capacity, diffusion lung capacity, and the extent of honeycombing, PH-specific agents also showed no significant association with a reduction in all-cause mortality. A small but significant improvement in quality of life, measured using the St. George Respiratory Questionnaire total score, was found in the PH-specific agent group (mean difference, -3.16 points; 95% CI, -5.34, -0.97; P = 0.005; I2 = 0%). We found no significant changes from baseline in lung function, dyspnea, or exercise capacity. Serious adverse events were similar between the two groups. Although PH-specific agents provided small health-related quality-of-life benefits, our meta-anal. provides insufficient evidence to support their use in IPF patients. In the experiment, the researchers used many compounds, for example, 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4Computed Properties of C23H32N6O4S).

2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Computed Properties of C23H32N6O4S

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Dummy molecularly imprinted solid phase extraction in a nylon membrane filter for analysis of vardenafil in health care products was written by Wan, Libin;Gao, Huoliang;Gao, Haidong;Yan, Ge;Wang, Fayun;Wang, Yong;Chen, Mantang. And the article was included in Microchemical Journal in 2021.Recommanded Product: 224785-90-4 This article mentions the following:

A novel dummy molecularly imprinted polymer (MIP) was prepared for highly specific recognition of vardenafil. Sildenafil was used as the template, and Fe-based metal-organic gel was in situ formed and acted as structural modulator and porogenic agent. The obtained MIP was demonstrated to have stronger binding affinity and higher binding capacity towards vardenafil than non-imprinted polymer (NIP). Adsorption processes of vardenafil on MIP and NIP were fitted well by Freundlich isotherm model. Combined with LC-MS anal. a miniaturized solid phase extraction (SPE) method using MIP as the adsorbent and using a syringe connected with a nylon membrane filter as the adsorbent container was developed. Under the optimal extraction parameters, trace vardenafil has been extraction by the developed method from the spiked water sample with satisfied recovery of 104%, and the intra- and inter-day relative standard deviations (RSDs) were below 7.3%. The linear range was 10-1000 ng mL^-1 (R² = 0.9996), and the limit of detection (LOD, S/N = 3) and limit of quantification (LOQ, S/N = 10) were 1.8 and 6.0μg L^-1, resp. Finally, the proposed MIP-SPE-LC/MS method was applied to discover vardenafil from health care products (HCPs) using standard addition method. The repeatability for both HCPs was below 6.3% (RSD values). Anal. results implied that the developed MIP-SPE-LC/MS method is green, convenient and useful to monitor the illegal additives in HCPs. In the experiment, the researchers used many compounds, for example, 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4Recommanded Product: 224785-90-4).

2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Recommanded Product: 224785-90-4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Development and validation of HPLC/DAD method for simultaneously determination of six prohibited substances in model matrices was written by Zaharieva, Zdravka;Tanev, Dimitar;Danalev, Dancho. And the article was included in Acta Chromatographica in 2020.HPLC of Formula: 224785-90-4 This article mentions the following:

The authorities have identified an emerging trend where over-the-counter products, represented as dietary supplements, contain hidden active ingredients that could be harmful. Consumers may unknowingly take products laced with varying quantities of approved prescription drug ingredients, controlled substances, and untested and unstudied pharmaceutically active ingredients. Hidden ingredients are increasingly becoming a problem in products promoted for sexual enhancement, weight loss, or bodybuilding. The tests have revealed the presence of some undesired substances like sildenafil, tadalafil, vardenafil, and their analogs in tainted sexual enhancement products. The content of these substances is usually around the daily curative dose. A simple high-performance liquid chromatog. (HPLC) method for simultaneously determination of sildenafil, vardenafil, tadalafil, dapoxetine, yohimbine, and sibutramine was developed and validated. InfinityLab Poroshell 120 EC-C18 (150 ‘4.6 mm ‘4μm particles) was used, as well as a diode-array detector (DAD) at 230 nm, and a gradient flow with 0.030 M ammonium acetate buffer and acetonitrile. The method is linear in the following range: 2.5-37.5μg/mL for yohimbine, 2.06-30.9μg/ mL for vardenafil, 2.0-30.0μg/mL for sildenafil, 3.1-46.5μg/mL for tadalafil, 1.98-29.7μg/mL for dapoxetine, and 2.2-66.0μg/mL for sibutramine. The linearity coefficient is R2 = 1 for all substances. Model matrixes were spiked, and the anal. recoveries for all substances are in the range 97.5%-99.5%. The method exhibited an upper hand compared with previously reported methods in terms of speed and simplicity. Addnl., the mobile phase (also used as extracting, column washing, and diluting solvent) was composed of only buffer and acetonitrile, which rendered the method much cheaper than others. In the experiment, the researchers used many compounds, for example, 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4HPLC of Formula: 224785-90-4).

2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.HPLC of Formula: 224785-90-4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The effect of phosphodiesterase-type 5 inhibitors on erectile function: an overview of systematic reviews was written by Pyrgidis, Nikolaos;Mykoniatis, Ioannis;Haidich, Anna-Bettina;Tirta, Maria;Talimtzi, Persefoni;Kalyvianakis, Dimitrios;Ouranidis, Andreas;Hatzichristou, Dimitrios. And the article was included in Frontiers in Pharmacology in 2021.SDS of cas: 224785-90-4 This article mentions the following:

Multiple systematic reviews explore the effect of phosphodiesterase type 5 (PDE5) inhibitors on erectile dysfunction (ED), with each study addressing specific outcomes. However, physicians and policymakers require a holistic approach of this topic. To summarize the current evidence regarding the efficacy and safety of PDE5 inhibitors for the management of ED through an overview of systematic reviews. Studies were identified by searching PubMed, Web of Science, Cochrane Library and Scopus databases, as well as sources of gray literature until June 12, 2021 (PROSPERO: CRD42020216754). We considered systematic reviews, meta-analyses or network meta-analyses of randomized trials that provided outcomes about the efficacy and safety of any approved PDE5 inhibitor (avanafil, sildenafil, tadalafil and vardenafil). We constructed forest plots for meta-analytic effects regarding the change in erectile function, adverse events and dropouts after administration of PDE5 inhibitors in the general population and in specific patient groups. We included 23 studies with 154,796 participants and a total of 258 meta-analytic effects. Sildenafil 25 mg [Weighted Mean Difference (WMD): 13.08, 95% Confidence Interval (CI): 10.1-16.06] seemed to be statistically superior to all interventions in improving erectile function compared to placebo, but studies with low-dose sildenafil are lacking. Moreover, comparing among different PDE5 inhibitors, sildenafil 50 mg or sildenafil 100 mg were considered the most effective compounds in the general population. The latter derived, however, predominantly from indirect comparisons among different PDE5 inhibitors. Still, sildenafil 100 mg was associated with more treatment-related adverse events and dropouts. Interestingly, low-dose daily tadalafil may be more effective than high-dose on-demand tadalafil (WMD: 1.24, 95% CI: 0.03-2.44). Furthermore, testosterone and PDE5 inhibitors in patients with ED and hypogonadism seem to further improve symptoms, while the addition of a-blockers in patients with urinary symptoms treated with PDE5 inhibitors does not provide addnl. benefits (WMD: -0.8, 95% CI: -1.65-0.06). Although the efficacy and safety of PDE5 inhibitors, compared to placebo, is well-documented, the existing evidence comparing different PDE5 inhibitors is low. Therefore, high-quality, head-to-head, trials comparing different PDE5 inhibitors are necessary to determine their ideal dosage and formulation based on their safety and efficacy profile. In the experiment, the researchers used many compounds, for example, 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4SDS of cas: 224785-90-4).

2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.SDS of cas: 224785-90-4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Microwave-assisted extraction followed by salting-out phase separation for hierarchical screening of illegal adulterants in aphrodisiac health products by multi-dimensional fingerprint profiling analysis was written by Wang, Ke;Jin, Peiyi;Pi, Jiaju;Xie, Xiujuan;Zhang, Yi;Yue, Zhenfeng;Mai, Xiaoman;Fan, Huajun;Zhang, Wei. And the article was included in Journal of Pharmaceutical and Biomedical Analysis in 2021.HPLC of Formula: 224785-90-4 This article mentions the following:

A novel method for hierarchical screening of illegal adulterants in Fur seal ginseng pills (FSGP) products was developed by microwave-assisted extraction (MAE) coupled to salting-out assisted liquid-liquid extraction (SALLE) with multi-dimensional fingerprint profiling anal. Using a homogeneous system formed by di-Me carbonate (DMC) and water as the extractant, the MAE conditions were investigated to maximize extraction recoveries, followed by addition of ammonium sulfate to induce DMC phase separation for SALLE enrichment of 16 potentially illegal adulterants such as phosphodiesterase type-5 inhibitors, androgens, α receptor antagonists and yohimbine etc. By means of high-performance liquid chromatog. (HPLC) with diode array detection (DAD) and fluorescence detection (FLD), multi-dimensional fingerprints were acquired by multi-wavelength detection to highlight the signals of the potentially illegal adulterants and reduce or remove interferences from the sample matrix. For high accuracy and reliability, a hierarchical screening strategy was designed by multi-dimensional fingerprinting profiling anal. (MDFPA). The method exhibited proper identification and quantification performance, and it was successfully applied to screening of illegal adulterants in 18 batches of the samples through the step-by-step MDFPA. Also, the results were further confirmed by ultra high-performance liquid chromatog.-quadrupole-orbitrap mass spectrometry (UHPLC-Q-Orbitrap/MS). The proposed method was proved to be a green, efficient and reliable alternative to monitoring aphrodisiac health products. In the experiment, the researchers used many compounds, for example, 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4HPLC of Formula: 224785-90-4).

2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).HPLC of Formula: 224785-90-4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Functional metabolomics reveal the role of AHR/GPR35 mediated kynurenic acid gradient sensing in chemotherapy-induced intestinal damage was written by Wang, Di;Li, Danting;Zhang, Yuxin;Chen, Jie;Zhang, Ying;Liao, Chuyao;Qin, Siyuan;Tian, Yuan;Zhang, Zunjian;Xu, Fengguo. And the article was included in Acta Pharmaceutica Sinica B in 2021.Category: piperazines This article mentions the following:

Intestinal toxicity induced by chemotherapeutics has become an important reason for the interruption of therapy and withdrawal of approved agents. In this study, we demonstrated that chemotherapeutics-induced intestinal damage were commonly characterized by the sharp upregulation of tryptophan (Trp)-kynurenine (KYN)-kynurenic acid (KA) axis metabolism Mechanistically, chemotherapy-induced intestinal damage triggered the formation of an interleukin-6 (IL-6)-indoleamine 2,3-dioxygenase 1 (IDO1)-aryl hydrocarbon receptor (AHR) pos. feedback loop, which accelerated kynurenine pathway metabolism in gut. Besides, AHR and G protein-coupled receptor 35 (GPR35) neg. feedback regulates intestinal damage and inflammation to maintain intestinal integrity and homeostasis through gradually sensing kynurenic acid level in gut and macrophage, resp. Moreover, based on virtual screening and biol. verification, vardenafil and linagliptin as GPR35 and AHR agonists resp. were discovered from 2388 approved drugs. Importantly, the results that vardenafil and linagliptin significantly alleviated chemotherapy-induced intestinal toxicity in vivo suggests that chemotherapeutics combined with the two could be a promising therapeutic strategy for cancer patients in clinic. This work highlights GPR35 and AHR as the guardian of kynurenine pathway metabolism and core component of defense responses against intestinal damage. In the experiment, the researchers used many compounds, for example, 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4Category: piperazines).

2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Combination therapy with topical alprostadil and phosphodiesterase-5 inhibitors after failure of oral therapy in patients with erectile dysfunction: a prospective, two-arm, open-label, non-randomized study was written by Garrido-Abad, Pablo;Senra-Bravo, Isabel;Manfredi, Celeste;Fernandez-Pascual, Esau;Linares-Espinos, Estefania;Fernandez-Arjona, Manuel;Varillas-Delgado, David;Martinez-Salamanca, Juan Ignacio. And the article was included in International Journal of Impotence Research in 2022.Synthetic Route of C23H32N6O4S This article mentions the following:

Abstract: To evaluate efficacy and safety of combination therapy with PDE5I and topical alprostadil in patients with ED non-responders to PDE5I alone. Patients over 18 years old, with stable sexual relationship for at least 6 mo, and ED non-responders to PDE5I monotherapy were included in study. At baseline the variables assessed were 5-item version of International Index of Erectile Function (IIEF-5), and Sexual Encounter Profile Questions 2 and 3 (SEP-2 and SEP-3). All patients were assigned to monotherapy group (Group A) or combination therapy group (Group B) based on their preference. 52 patients were previously treated with sildenafil 100 mg (30.6%), 6 with vardenafil 20 mg (3.5%), 56 with tadalafil 20 mg (32.9%), and 56 with avanafil 200 mg (32.9%). Mean IIEF-5 score increased significantly in Group B after treatment compared to baseline, conversely patients in Group A showed no increase. Number of affirmative responses to SEP-2 was higher after treatment compared to baseline only in Group B. Number of affirmative responses to SEP-3 was higher after treatment compared to baseline in both groups (p < 0.001). Number of affirmative responses to GAQ-Q1 and GAQ-Q2 was significantly higher in Group B compared to Group A (p < 0.001). A total of 59 (34.7%) patients experienced AEs. No episode of priapism was recorded. Combination therapy with topical alprostadil and PDE5I seems to be more effective than topical alprostadil alone without worsening safety of the treatment. In the experiment, the researchers used many compounds, for example, 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4Synthetic Route of C23H32N6O4S).

2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Synthetic Route of C23H32N6O4S

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Low-dose vardenafil potentiates the protective effect of (-)-epigallocatechin gallate on cardiomyocytes was written by Wang, Kai;Fan, Zhaoyang;Jin, Peng;Qin, Dingkui;Du, Qizhen. And the article was included in Pakistan Journal of Pharmaceutical Sciences in 2020.Synthetic Route of C23H32N6O4S This article mentions the following:

The major polyphenol (-)-epigallocatechin gallate (EGCG) of green tea shows well-known health benefits such as potential anti-cancer, anti-oxidation and ameliorating cardiovascular disease. This work aims to improve the bioactivity of EGCG on H9C2 cardiomyocytes by combination regimen of vardenafil and EGCG. The proliferative rates were significantly improved by 18.74%, 10.77% and 29.17% after 48 h with EGCG, vardenafil, and the combination of EGCG and low-dose vardenafil treatments, resp. The treatments also increased the expression of the nitric oxide synthase (eNOS), and acutely stimulate production of vasodilators nitric oxide (NO) from 17.33micromol/L to 19.75, 20.87 and 24.47μmol/L in H9C2 cells. We further demonstrated that vardenafil also remarkably promoted EGCG to counteract H2O2-induced apoptotic damage in H9C2 by strengthening antioxidant defense systems and suppressing myocardial apoptosis. These results suggest that EGCG and low-dose vardenafil in combination may be a promising regimen to help prevent cardiovascular diseases. In the experiment, the researchers used many compounds, for example, 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4Synthetic Route of C23H32N6O4S).

2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Synthetic Route of C23H32N6O4S

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Intersystem extrapolation factors are substrate-dependent for CYP3A4: impact on cytochrome P450 reaction phenotyping was written by Dantonio, Alyssa L.;Doran, Angela C.;Obach, R. Scott. And the article was included in Drug Metabolism & Disposition in 2022.Safety of 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one This article mentions the following:

The use of intersystem extrapolation factors (ISEF) is required for the quant. scaling of drug metabolism data generated in individually expressed cytochrome P 450 (CYP) enzymes when estimating fractional contribution (fm) to metabolism by P 450 enzymes in vivo. For successful prediction of fm, ISEF values must be universal across all substrates for any individual enzyme. In this study, ISEF values were generated for ten CYP3A4 selective substrates using a common source of recombinant heterologously expressed CYP3A4 (rCYP) and a pool of human liver microsomes. The resulting ISEF values for CYP3A4 were substrate-dependent and ranged 8-fold, with the highest value generated from intrinsic clearance of midazolam depletion (0.36) and the lowest from quinidine depletion (0.044). Application of these ISEF values for estimation of the fractional contribution of CYP3A4 and CYP2C19 to omeprazole clearance yielded values that ranged from 0.21-0.63 and 0.37-0.79, resp., as compared with back-extrapolated in vivo fm values of 0.27 (CYP3A4) and 0.85 (CYP2C19) from clin. pharmacokinetic data. For risperidone, estimated fm values for CYP3A4 and CYP2D6 ranged from 0.87-0.98 and 0.02-0.13, resp., as compared with in vivo values of 0.36 (CYP3A4) and 0.63-0.88 (CYP2D6), showing that the importance of CYP3A4 was overestimated, and the importance of CYP2D6 underestimated. Overall, these findings suggest that ISEF values for CYP3A4 can vary with the marker substrate used to derive them, thereby reducing the effectiveness of the approach of using metabolism data from rCYP3A4 with ISEF values for the prediction of fraction metabolized values in vivo. In the experiment, the researchers used many compounds, for example, 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4Safety of 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one).

2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Safety of 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Utility of Gold Nanoparticles for Spectrofluorimetric and Spectrophotometric Determination of Sildenafil Citrate, Dapoxetine, Vardenafil and Tadalafil in their Dosage Forms and Biological Fluids was written by Salem, Hesham;Abdel Aziz, Basma E.. And the article was included in Analytical Chemistry Letters in 2020.Electric Literature of C23H32N6O4S This article mentions the following:

Two simple, rapid and novel sensitive fluorimetric and spectrophotometric methods were investigated for the assay of sildenafil citrate (SIL), dapoxetine (DAP), vardenafil (VAD) and tadalafil (TAD) using gold nanoparticles (Au NPs). On the spectrofluorimetric method, gold nanoparticles were used as a fluorescence probe. The addition of drugs to Au-NPs solution caused considerable quenching of the emission band of Au-NPs, which was likely due to the complexation of the drug to gold NPs. Under the optimum conditions, the quenched fluorescence (FL) intensity was linear with the studied concentrations The quenching mechanism of the studied drugs on the emission band of Au-NPs was explained by Stern-Volmer law. The second spectrophotometric method was based on aggregation of synthesized gold nanoparticles. Gold nanoparticles showed absorption at 522 nm. Upon interaction with the cited drugs, the band at 522 nm disappeared with the formation of a new red-shifted band at 673, 660, 665, and 663 nm for SIL, TAD, VAD, and DAP, resp. Different exptl. factors were optimized for higher sensitivity. The calibration curves were linear with a concentration range of 0.1-12 μg/mL for the studied drugs. The methods were applied successfully to determine the studied drugs in minor concentrations in pure form, pharmaceutical dosage forms, and biol. fluids (human serum and urine). In the experiment, the researchers used many compounds, for example, 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4Electric Literature of C23H32N6O4S).

2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Electric Literature of C23H32N6O4S

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics