Tag: 204.2682

Borthwick, Alan D. et al. published their research in Journal of Medicinal Chemistry in 2005 | CAS: 27913-99-1

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. SDS of cas: 27913-99-1

2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists. 2. Synthesis, Chirality, and Pharmacokinetics was written by Borthwick, Alan D.;Davies, Dave E.;Exall, Anne M.;Livermore, David G.;Sollis, Steve L.;Nerozzi, Fabrizio;Allen, Michael J.;Perren, Marion;Shabbir, Shalia S.;Woollard, Patrick M.;Wyatt, Paul G.. And the article was included in Journal of Medicinal Chemistry in 2005.SDS of cas: 27913-99-1 This article mentions the following:

A short stereoselective synthesis of a series of chiral 7-aryl-2,5-diketopiperazines oxytocin antagonists is described. Varying the functionality and substitution pattern of substituents in the 7-aryl ring and varying the chirality of this exocyclic ring have produced potent oxytocin antagonists (pKi > 8.5). SAR and pharmacokinetic profiling of this series of (3R,6R,7R)-2,5-diketopiperazines together with the introduction of an ortho F group in the 7-aryl ring to improve rat pK has culminated in the 2′,4′-difluorophenyldiketopiperazine derivative I, a highly potent oxytocin antagonist against the human oxytocin receptor (pKi = 8.9) that has >1000-fold selectivity over all three vasopressin receptors V1a, V2, and V1b. It has good bioavailability (46%) in the rat and moderate bioavailability (13-31%) in the dog and is more active in vivo in the rat than atosiban (rat DR10 = 0.44 mg/kg iv). In the experiment, the researchers used many compounds, for example, 4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1SDS of cas: 27913-99-1).

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. SDS of cas: 27913-99-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

 

Shah, N. N. S. et al. published their research in Chemica Sinica in 2011 | CAS: 27913-99-1

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Category: piperazines

Synthesis and antimicrobial studies of a novel series of piperazine chalcones was written by Shah, N. N. S.;Ziauddin, Hanfi M.;Zameer, Mohammed;Kendre, M. M.;Dhole, J. A.;Baseer, M. A.. And the article was included in Chemica Sinica in 2011.Category: piperazines This article mentions the following:

A series of novel chalcones were synthesized via Claisen-Schmidt condensation of substituted ketones and 4-(4-methylpiperazin-1-yl)benzaldehyde. These newly synthesized compounds were characterized by phys., chem. and spectral anal. data and are further screened for their antimicrobial activity. The newly synthesized chalcones showed moderate to good antimicrobial activity. In the experiment, the researchers used many compounds, for example, 4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1Category: piperazines).

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

 

Harper, Norman J. et al. published their research in Journal of Medicinal Chemistry in 1964 | CAS: 949-69-9

1-Benzylpiperidin-4-one oxime (cas: 949-69-9) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Category: piperidines

The chemistry and pharmacology of some 4-aminopiperidines and their derivatives was written by Harper, Norman J.;Chignell, Colin F.. And the article was included in Journal of Medicinal Chemistry in 1964.Category: piperidines This article mentions the following:

A number of 4-aminopiperidines and their derivatives (I) have been synthesized and assessed pharmacol. for central nervous system activity. These compounds were prepared from the corresponding piperidones, which were converted to their oximes and then reduced to the amino compounds In the experiment, the researchers used many compounds, for example, 1-Benzylpiperidin-4-one oxime (cas: 949-69-9Category: piperidines).

1-Benzylpiperidin-4-one oxime (cas: 949-69-9) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Altomare, C. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2000 | CAS: 949-69-9

1-Benzylpiperidin-4-one oxime (cas: 949-69-9) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Safety of 1-Benzylpiperidin-4-one oxime

Pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation was written by Altomare, C.;Summo, L.;Cellamare, S.;Varlamov, A. V.;Voskressensky, L. G.;Borisova, T. N.;Carotti, A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2000.Safety of 1-Benzylpiperidin-4-one oxime This article mentions the following:

A series of pyrrolo[3,2-c]pyridines, isosteres of the antithrombotic drug ticlopidine, has been synthesized and evaluated in vitro for the ability to inhibit aggregation of human platelet-rich plasma induced by ADP. Structure-activity relationships showed their antiplatelet effects to be related to the lipophilicity. In the experiment, the researchers used many compounds, for example, 1-Benzylpiperidin-4-one oxime (cas: 949-69-9Safety of 1-Benzylpiperidin-4-one oxime).

1-Benzylpiperidin-4-one oxime (cas: 949-69-9) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Safety of 1-Benzylpiperidin-4-one oxime

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Altomare, C. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2000 | CAS: 949-69-9

1-Benzylpiperidin-4-one oxime (cas: 949-69-9) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Safety of 1-Benzylpiperidin-4-one oxime

Pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation was written by Altomare, C.;Summo, L.;Cellamare, S.;Varlamov, A. V.;Voskressensky, L. G.;Borisova, T. N.;Carotti, A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2000.Safety of 1-Benzylpiperidin-4-one oxime This article mentions the following:

A series of pyrrolo[3,2-c]pyridines, isosteres of the antithrombotic drug ticlopidine, has been synthesized and evaluated in vitro for the ability to inhibit aggregation of human platelet-rich plasma induced by ADP. Structure-activity relationships showed their antiplatelet effects to be related to the lipophilicity. In the experiment, the researchers used many compounds, for example, 1-Benzylpiperidin-4-one oxime (cas: 949-69-9Safety of 1-Benzylpiperidin-4-one oxime).

1-Benzylpiperidin-4-one oxime (cas: 949-69-9) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Safety of 1-Benzylpiperidin-4-one oxime

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Altomare, C. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2000 | CAS: 949-69-9

1-Benzylpiperidin-4-one oxime (cas: 949-69-9) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Safety of 1-Benzylpiperidin-4-one oxime

Pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation was written by Altomare, C.;Summo, L.;Cellamare, S.;Varlamov, A. V.;Voskressensky, L. G.;Borisova, T. N.;Carotti, A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2000.Safety of 1-Benzylpiperidin-4-one oxime This article mentions the following:

A series of pyrrolo[3,2-c]pyridines, isosteres of the antithrombotic drug ticlopidine, has been synthesized and evaluated in vitro for the ability to inhibit aggregation of human platelet-rich plasma induced by ADP. Structure-activity relationships showed their antiplatelet effects to be related to the lipophilicity. In the experiment, the researchers used many compounds, for example, 1-Benzylpiperidin-4-one oxime (cas: 949-69-9Safety of 1-Benzylpiperidin-4-one oxime).

1-Benzylpiperidin-4-one oxime (cas: 949-69-9) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Safety of 1-Benzylpiperidin-4-one oxime

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Altomare, C. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2000 | CAS: 949-69-9

1-Benzylpiperidin-4-one oxime (cas: 949-69-9) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Safety of 1-Benzylpiperidin-4-one oxime

Pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation was written by Altomare, C.;Summo, L.;Cellamare, S.;Varlamov, A. V.;Voskressensky, L. G.;Borisova, T. N.;Carotti, A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2000.Safety of 1-Benzylpiperidin-4-one oxime This article mentions the following:

A series of pyrrolo[3,2-c]pyridines, isosteres of the antithrombotic drug ticlopidine, has been synthesized and evaluated in vitro for the ability to inhibit aggregation of human platelet-rich plasma induced by ADP. Structure-activity relationships showed their antiplatelet effects to be related to the lipophilicity. In the experiment, the researchers used many compounds, for example, 1-Benzylpiperidin-4-one oxime (cas: 949-69-9Safety of 1-Benzylpiperidin-4-one oxime).

1-Benzylpiperidin-4-one oxime (cas: 949-69-9) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Safety of 1-Benzylpiperidin-4-one oxime

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem