Tag: 159.0575

Anthemintic drugs. Their ovicidal and larvicidal actions was written by Goulart, Enio G.;De Arruda, Mercia E.;Jourdan, Myriam C.. And the article was included in Revista Brasileira de Medicina in 1974.Quality Control of Piperazine Dihydrochloride This article mentions the following:

Of 9 chemotherapeutic anthelmintics tested in vitro against eggs and larvae of Ascaris lumbricoides, Trichuris trichiura, and Ancylostoma caninum, pyrantel pamoate [22204-24-6] and tetrachloroethylene [127-18-4] (10 and 100 mg each) inhibited development of A. caninum; similar results were obtained with 1 mg tetramisole-HCl (I-HCl) [5086-74-8] and thiabendazole (II) [148-79-8]. Stilbazium iodide [3784-99-4], pyrvinium pamoate [3546-41-6], and bephenium hydroxynaphthoate [3818-50-6] showed anthelmintic activity which was directly related to the concentrations None of the compounds tested showed embryogenic blocking activity against A. lumbricoides or T. trichiura. Prophylactic treatments of contaminated soil or organic fertilizer are apparently ineffective. In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Quality Control of Piperazine Dihydrochloride).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Quality Control of Piperazine Dihydrochloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Piperazino biguanides as cysticidal agents was written by Sharma, M.;Shanker, K.;Nath, Renu;Bhargava, K. P.;Kishor, K.. And the article was included in Indian Journal of Pharmacy in 1977.Reference of 142-64-3 This article mentions the following:

Of 19 piperazino biguanide derivatives (I) prepared and tested for ameba cysticidal activity, II (I, R = H, X = N-Ph) [65968-12-9] was the most active. The cysticidal activities of II in concentrations of 0.5, 0.25, 0.125, 0.0625, 0.0312, and 0.0156 mg/mL were 100, 75.5, 48.0, 19.5, 9.0, and 0%, resp. Amebicidal activity was not detected in any of the 19 I derivatives In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Reference of 142-64-3).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Reference of 142-64-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Newly synthesized fluorinated cinnamylpiperazines possessing low in vitro MAO-B binding was written by Jevtic, Ivana I.;Lai, Thu Hang;Penjisevic, Jelena Z.;Dukic-Stefanovic, Sladjana;Andric, Deana B.;Brust, Peter;Kostic-Rajacic, Sladjana V.;Teodoro, Rodrigo. And the article was included in Molecules in 2020.COA of Formula: C4H12Cl2N2 This article mentions the following:

Herein, the synthesis and pharmacol. evaluation of ten novel fluorinated cinnamylpiperazines I (R = 2-fluorophenyl, phenyl; R¹ = (4-fluorophenyl)carbonyl, 2-fluoropyridin-3-yl, 6-fluoropyridin-2-yl, etc.)as potential monoamine oxidase B (MAO-B) ligands were reported. The designed derivatives I consist of either cinnamyl or 2-fluorocinnamyl moieties connected to 2-fluoropyridylpiperazines. The three-step synthesis starting from com. available tert-Bu piperazine-1-carboxylate afforded the final products I in overall yields between 9% and 29%. An in vitro competitive binding assay using l-[³H]Deprenyl as radioligand was developed and the MAO-B binding affinities of the synthesized derivatives I were assessed. Docking studies revealed that the compounds I were stabilized in both MAO-B entrance and substrate cavities, thus resembling the binding pose of l-Deprenyl. Although the results revealed that the novel fluorinated cinnamylpiperazines I do not possess sufficient MAO-B binding affinity to be eligible as positron emission tomog. (PET) agents, the herein developed binding assay and the insights gained within our docking studies will certainly pave the way for further development of MAO-B ligands. In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3COA of Formula: C4H12Cl2N2).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.COA of Formula: C4H12Cl2N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis and transformations of the copper(II) N-(2-aminoethyl)aziridine and N-(2-haloethyl)ethylenediamine complexes was written by Ukraintsev, V. B.;Esikov, K. A.;Krasnov, B. A.;Potekhin, V. V.. And the article was included in Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) in 1997.Name: Piperazine Dihydrochloride This article mentions the following:

The Cu(II) complexes with N-(2-aminoethyl)aziridine (L’) and N-(2-haloethyl)ethylenediamine (L”) with the mol. compositions [CuLX₂] and [CuL₂X₂] (L = L’ or L”, X = Cl or Br) were synthesized. According to the IR spectra, [CuLX₂] are coordination polymers consisting of tetrahedrally distorted hexacoordinated species. [CuLBr₂] disproportionates in H₂O to form [CuL₂Br₂]. Refluxing of [CuLX₂] and [CuL₂X₂] in BuOH results in intraspheric transformation of their L ligands into piperazine. Reaction of all the obtained Cu(II) derivatives with formaldehyde initiates formation of the piperazine ring. In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Name: Piperazine Dihydrochloride).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Name: Piperazine Dihydrochloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis and thermal reactions of 2-haloethylamine nickel(II) complexes was written by Ukraintsev, V. B.;Radzhabov, T.;Yakovlev, S. V.;Kukushkin, Yu. N.. And the article was included in Zhurnal Obshchei Khimii in 1987.Product Details of 142-64-3 This article mentions the following:

[Ni(NH₂CH₂CH₂X)₄X₂] (I; X = Cl, Br) were prepared by reaction of (XCH₂CH₂NH₃)₄[NiX₄] with NaOH. Solid-phase thermal reactions of I gave Ni(NH₂CH₂CH₂NHCH₂CH₂X)₂X₂ at 100-140° and piperazine dihydrohalide and NiX₂ at 160-210°. In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Product Details of 142-64-3).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Product Details of 142-64-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis of ethyleneamines. III. Pyrolysis of N,N’-bis(2-hydroxyethyl)ethylenediamine hydrochloride was written by Tkaczynski, Tadeusz. And the article was included in Acta Poloniae Pharmaceutica in 1958.COA of Formula: C4H12Cl2N2 This article mentions the following:

N,N’-Bis(2-hydroxyethyl)ethylenediamine – HCl heated 2.5 hrs. at 260° yielded piperazine-HCl (I). A similar process carried out at 200° gave I and N-piperazineëthanol-HCl (II). II on similar heating at 260° was converted into I. In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3COA of Formula: C4H12Cl2N2).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.COA of Formula: C4H12Cl2N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

A simple blue fluorescent probe to detect Hg²⁺ in semiaqueous environment by intramolecular charge transfer mechanism was written by Srivastava, Priyanka;Ali, Rashid;Razi, Syed S.;Shahid, Mohammad;Patnaik, Satyakam;Misra, Arvind. And the article was included in Tetrahedron Letters in 2013.Product Details of 142-64-3 This article mentions the following:

An efficient intramol. charge transfer fluorescent probe bridging benzhydryl moiety and dansyl fluorophore through piperazine unit was synthesized and characterized. The photophys. behavior of synthesized probe was analyzed in the presence of different cations in aqueous acetonitrile solution The probe showed sensitivity to detect Hg²⁺ ion selectively over other tested cations at 20 nM level. The probable mode of binding of Hg²⁺ through the nitrogen and oxygen atoms of piperazine and dansyl was established by spectral data anal. In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Product Details of 142-64-3).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Product Details of 142-64-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of tumor growth and tumor angiogenesis of mouse ehrlich ascites tumor in vivo was written by Ananda Kumar, C. S.;Chandru, H.;Sharada, A. C.;Thimmegowda, N. R.;Benaka Prasad, S. B.;Kumar, M. Karuna;Rangappa, K. S.. And the article was included in Medicinal Chemistry in 2008.Reference of 142-64-3 This article mentions the following:

A series of novel 1-benzhydryl-sulfonyl-piperazine derivatives 3(a-e) were synthesized by nucleophilic substitution reaction of 1-benzhydryl-piperazine with different sulfonyl chlorides and were characterized by ¹H NMR, LC/MS, FTIR and elemental anal. In the present study, the compounds 3(a-e) exhibited in vivo inhibition of Ehrlich ascites tumor (EAT) cell growth and increased the Median Survival Time (MST) and %ILS of EAT bearing mice. Further treatment of derivatives in vivo resulted in reduction of EAT cell number and ascites formation. The efficacy of the derivatives to inhibit the angiogenesis in vivo was evaluated in tumor bearing mice peritoneum and chorio allantoic membrane (CAM) model. The compounds suppressed the blood vessel formation in vivo in mice peritoneum and in CAM. Among the compounds studied, 3e demonstrated highest tumor inhibitory and anti-angiogenic effects against mouse tumor. However, this phenomenon needs detailed investigation. In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Reference of 142-64-3).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Reference of 142-64-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis of piperazine and its salts was written by Krishnan, V.;Muthkumaran, A.;Udupa, H. V. K.. And the article was included in Indian Journal of Technology in 1975.Electric Literature of C4H12Cl2N2 This article mentions the following:

Dioxopiperazine was prepared from glycine and then reduced electrolytically at low temperature to piperazine at Pb and Cu amalgamated electrodes. Piperazine dihydrochloride and citrate were prepared Zn dust distillation of piperazine gave pyrazine. In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Electric Literature of C4H12Cl2N2).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Electric Literature of C4H12Cl2N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Comparative studies of emesis in pigeons and dogs was written by Koster, Rudolf. And the article was included in Journal of Pharmacology and Experimental Therapeutics in 1957.Recommanded Product: Piperazine Dihydrochloride This article mentions the following:

Comparative studies of emesis were made in pigeons and dogs by using the emetic drugs apomorphine, CuSO₄, and piperazine-HCl, and the antiemetic drugs cyclizine, atropine, scopolamine, and chlorpromazine in various dosages and combinations. Emetic, antiemetic, and other effects are reported, and the possible mechanisms of action are discussed. In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Recommanded Product: Piperazine Dihydrochloride).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Recommanded Product: Piperazine Dihydrochloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics