Biological Effect Evaluation of Different Sized Titanium Dioxide Nanoparticles Using Bombyx mori (Silkworm) as a Model Animal was written by Fometu, Sandra Senyo;Ma, Qiang;Wang, JinJin;Guo, Jianjun;Ma, Lin;Wu, Guohua. And the article was included in Biological Trace Element Research in 2022.Product Details of 85721-33-1 This article mentions the following:
Titanium dioxide nanoparticles (TiO2 NPs) are widely used in various disciplines, and it is imperative to evaluate their safety in the environment. In this paper, Bombyx mori (silkworm) was used as a model organism to evaluate the biol. effects of different sized TiO2 NPs, taking into consideration their effect on the larval growth, cocoon shell weight, tissues, and silk produced. The effect of the different sized TiO2 NPs on the larval and cocoon shell weight was dose-dependent. The highest accumulation of titanium (Ti) following a modified TiO2 NPs-treated mulberry diet was observed in the midgut. The expression of the light chain fibroin (FIBL) was three times higher in 0.33 g TiO2 NPs-treated silk gland after 96 h. X-ray diffraction (XRD) and Fourier transform IR (FTIR) anal. demonstrated that TiO2 NPs-treated silk fiber (TiSF) exhibited a diminutive decrease in silk fiber (SF) crystallization and β-sheet compared to the control SF, resp. The tensile tests of SF from silkworm fed with 0.03 g of 25 nm TiO2 NPs were significantly improved when compared to the control SF. Significant changes in the surface morphol. and thermal stability of SF were observed The antimicrobial activity of TiSF was investigated against Pseudomonas aeruginosa and Staphylococcus aureus, with ciprofloxacin-treated SF acting as a control. It was documented that 0.09 g of 60 nm TiSF was most effective against P. aeruginosa at a zone of inhibition (ZOI) of 21.06 mm when compared with the control SF which recorded a ZOI of 17.19 mm. This study highlighted a different approach in evaluating the biol. effects of TiO2 NPs using the silkworm as a model and assessing their impact on the silk intrinsic property, which will be effective in biotechnol. applications. In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 85721-33-1Product Details of 85721-33-1).
1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 85721-33-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Product Details of 85721-33-1
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics