A magnetic nanocomposite optosensing probe based on porous graphene, selective polymer and quantum dots for the detection of cefoperazone in milk was written by Chaitong, Nuntanut;Chansud, Nutnicha;Orachorn, Naphatsakorn;Limbut, Warakorn;Bunkoed, Opas. And the article was included in Microchemical Journal in 2021.SDS of cas: 62893-19-0 This article mentions the following:
An optosensor based on synthesized magnetic composite sensing probes was designed to detect ultra-trace levels of cefoperazone. The nanocomposite probe integrated porous graphene, quantum dots, magnetite nanoparticles and highly specific polymer. These substances produced an ultra-sensitive, selective and rapid sensor. The fluorescence emission of the nanoprobes was quenched when cefoperazone interacted with the imprinted binding sites. The developed probe exhibited good linearity toward cefoperazone from 0.10 to 25.0μg L-1 and the limit of detection was 0.09μg L-1. The fabricated magnetic nanocomposite sensor showed good specificity for cefoperazone with an imprinting factor of 7.5 and was not interfered by the analog structures ceftriaxone, cefazolin, cefradine, ceftazidime and cefalexin. The nanocomposite probe successfully detected cefoperazone in milk. Recoveries ranged from 85.3 to 98.3% with RSDs < 6%. Anal. results agreed well with HPLC but the advantages of the optosensor include a simple, rapid procedure, cost-effective equipment and environmental friendliness. In the experiment, the researchers used many compounds, for example, (6R,7R)-7-((R)-2-(4-Ethyl-2,3-dioxopiperazine-1-carboxamido)-2-(4-hydroxyphenyl)acetamido)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (cas: 62893-19-0SDS of cas: 62893-19-0).
(6R,7R)-7-((R)-2-(4-Ethyl-2,3-dioxopiperazine-1-carboxamido)-2-(4-hydroxyphenyl)acetamido)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (cas: 62893-19-0) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.SDS of cas: 62893-19-0
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics