Category: piperidines

SDS of cas: 826-36-8On May 5, 2022 ,《Modulated construction of Fe-based MOF via formic acid modulator for enhanced degradation of sulfamethoxazole:Design, degradation pathways, and mechanism》 appeared in Journal of Hazardous Materials. The author of the article were Sun, Jian; Wan, Jinquan; Wang, Yan; Yan, Zhicheng; Ma, Yongwen; Ding, Su; Tang, Min; Xie, Yongchang. The article conveys some information:

Metal-organic frameworks (MOFs) have attracted more attention because of their excellent environmental catalytic capabilities. Modulation approach as an advanced assistant strategy is vital essential to enhancing the performance of MOFs. In this study, the modulated method was used to successfully synthesize a group of Fe-based MOFs, with formic acid as the modulator on the synthesis mixture The most modulated sample Fe-MOFs-2 exhibit high sp. surface areas and higher catalytic activity, which could effectively degrade SMX via PS activation, with almost 95% removal efficiency within 120 min. The results revealed that the % RSE of modulated Fe-MOFs-2 increased from 2.31 to 3.27 when compared with the origin Fe-MOFs. This may be due to the addition of formic acid induces the formation of more coordinatively unsaturated metal sites in the catalyst, resulting in structural defects. In addition, the quenching experiment and EPR anal. verified SO-4·and·OH as the major active free radicals in the degradation process. Modulated Fe-MOFs-2 demonstrated good reusability and stability under fifth cycles. Finally, four possible degradation pathways and catalytic mechanism of Fe-MOFs-2 was tentatively proposed. Our work provides insights into the rational design of modulated Fe-MOFs as promising heterogeneous catalysts for advanced wastewater treatment. The experimental part of the paper was very detailed, including the reaction process of Triacetonamine(cas: 826-36-8SDS of cas: 826-36-8)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.SDS of cas: 826-36-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Category: piperidinesOn May 5, 2022 ,《Monodispersed CuO nanoparticles supported on mineral substrates for groundwater remediation via a nonradical pathway》 appeared in Journal of Hazardous Materials. The author of the article were Wang, Gen; Zhang, Yue; Ge, Lei; Liu, Zhuoyue; Zhu, Xiurong; Yang, Shengjiong; Jin, Pengkang; Zeng, Xiangkang; Zhang, Xiwang. The article conveys some information:

Nonradical oxidation based on singlet oxygen (1O2) has attracted great interest in groundwater remediation due to the selective oxidation property and good resistance to background constituents. Herein, recoverable CuO nanoparticles (NPs) supported on mineral substrates (SiO2) were prepared by calcination of surface-coated metal-plant phenolic networks and explored for peroxymonosulfate (PMS) activation to generate 1O2 for degrading organic pollutants in groundwater. CuO NPs with a close particle size (40 nm) were spatially monodispersed on SiO2 substrates, allowing highly exposure of active sites and consequently leading to outstanding catalytic performance. Efficient removal of various organic pollutants was obtained by the supported CuO NPs/PMS system under wide operation conditions, e.g., working pH, background anions and natural organic matters. Chem. scavenging experiments, ESR tests, furfuryl alc. decay and solvent dependency experiments confirmed the formation of 1O2 and its dominant role in pollutants removal. In situ characterization with ATR-FTIR and Raman spectroscopy and computational calculation revealed that a redox cycle of surface Cu(II)-Cu(III)-Cu(II) was responsible for the generation of 1O2. The feasibility of the supported CuO NPs/PMS for actual groundwater remediation was evaluated via a flow-through test in a fixed-bed column, which manifested long-term durability, high mineralization ratio and low metal ion leaching. The experimental part of the paper was very detailed, including the reaction process of Triacetonamine(cas: 826-36-8Category: piperidines)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

《Design, physico-chemical characterization and in vitro biological activity of organogold(III) glycoconjugates》 was published in Dalton Transactions in 2021. These research results belong to Pettenuzzo, Andrea; Vezzu, Keti; Di Paolo, Maria Luisa; Fotopoulou, Eirini; Marchio, Luciano; Via, Lisa Dalla; Ronconi, Luca. Safety of Piperidine-4-carboxamide The article mentions the following:

To develop new metal-based glycoconjugates as potential anticancer agents, four organometallic Au(III)-dithiocarbamato glycoconjugates [Au(III)(2-Bnpy)(SSC-Inp-GlcN)](PF6) (2-Bnpy: 2-benzylpyridine; Inp: isonipecotic moiety; GlcN: amino-glucose scaffold; Au3-Au6) and the corresponding model nonglycosylated counterparts [Au(III)(2-Bnpy)(SSC-Inp-R)](PF6) (R: OEt (Au1), NH2 (Au2)) were generated and characterized by several anal. techniques (elemental anal., FTIR, 1H-/13C-NMR, ESI-MS, UV-visible, x-ray crystallog.). Their stability under physiol.-relevant conditions (PBS solution) and n-octanol/PBS distribution coefficient (D7.4) also were evaluated. Au(III) glycoconjugates showed an antiproliferative effect against ovarian carcinoma A2780 cells, with GI50 values in the low micromolar range. Remarkably, their cell growth inhibitory effect increases upon the addition of a glucose transporter 1 (GLUT1) inhibitor, thus ruling out the involvement of GLUT1 in their transport inside the cell. Addnl. mechanistic studies were carried out in A2780 cells, supporting the hypothesis of a facilitated diffusion mechanism (possibly mediated by glucose transporters other than GLUT1), and revealing their capability to act as topoisomerase I and II inhibitors and to disrupt mitochondrial membrane integrity, giving ROS, thus resulting in the promotion of oxidative stress and, eventually, cell death. In addition to this study using Piperidine-4-carboxamide, there are many other studies that have used Piperidine-4-carboxamide(cas: 39546-32-2Safety of Piperidine-4-carboxamide) was used in this study.

Piperidine-4-carboxamide(cas: 39546-32-2) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Safety of Piperidine-4-carboxamide

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

《Development of phenazine-2,3-diol-based photosensitizers: effect of formyl groups on singlet oxygen generation》 was published in Materials Chemistry Frontiers in 2021. These research results belong to Ohira, Kazuki; Imato, Keiichi; Ooyama, Yousuke. Category: piperidines The article mentions the following:

Phenazine-2,3-diol derivatives KO-0-3, which have zero to three formyl groups, resp., have been developed as photosensitizers (PSs) possessing the ability to generate singlet oxygen (1O2). The photoabsorption bands of KO-0-3 are significantly red-shifted compared to those of phenazine-2,3-MOM (methoxymethyl) derivatives 5-8, whose hydroxy and formyl groups are protected, and have onsets at around 600-650 nm. Furthermore, the fluorescence quantum yields (Φfl) of KO-0-3 (Φfl = 0.024-0.097) are lower than those of 5-8 (Φfl = 0.34-0.46) in solution To gain insight into the 1O2 generation properties of KO-0-3, we evaluated the 1O2 quantum yields (ΦΔ) and rate constants (kobs), and demonstrated that KO-1-3 possess a higher ability to generate 1O2 under visible light irradiation than those of 5-8. Moreover, it was found that the ΦΔ values of KO-0-3 increase in the order of KO-0 (0.036) < KO-1 (0.22) < KO-2 (0.33) < KO-3 (0.41) with increasing number of formyl groups. This result indicates that formyl groups facilitate the intersystem crossing (ISC) from the lowest singlet excited states of the PSs (S1) to the triplet excited states (Tn) according to El-Sayed′s rule. Consequently, this work provides useful knowledge in mol. design of efficient phenazine-2,3-diol-based PSs for photodynamic therapy (PDT). In the experimental materials used by the author, we found Triacetonamine(cas: 826-36-8Category: piperidines)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

《A stochastic model for the synthesis and degradation of natural organic matter. Part III: Modeling Cu(II) complexation》 was written by Cabaniss, Stephen E.; Maurice, Patricia A.; Madey, Greg. Quality Control of Cis-piperidine-2,6-dicarboxylic acid And the article was included in Applied Geochemistry on August 31 ,2007. The article conveys some information:

An agent-based biogeochem. model has been developed which begins with biochem. precursor mols. and simulates the transformation and degradation of natural organic matter (NOM). This paper presents an empirical quant. structure activity relationship (QSAR) which uses the numbers of ligand groups, charge d. and heteroatom d. of a mol. to estimate Cu-binding affinity (K’Cu) at pH 7.0 and ionic strength 0.10 for the mols. in this model. Calibration of this QSAR on a set of 41 model compounds gives a root mean square error of 0.88 log units and r2 =0.93. Two simulated NOM assemblages, one beginning with small mols. (tannins, terpenoids, flavonoids) and one with biopolymers (protein, lignin), give markedly different distributions of log K’Cu. However, calculations based on these log K’Cu distributions agree qual. with published exptl. Cu(II) titration data from river and lake NOM samples. In the part of experimental materials, we found many familiar compounds, such as Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1Quality Control of Cis-piperidine-2,6-dicarboxylic acid)

Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Quality Control of Cis-piperidine-2,6-dicarboxylic acid

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2022,Yang, Chaofu; Sun, Xianyu; Li, Zhan; Cheng, Yunyun; Lei, Yu; Lu, Liang; Liu, Xuan; Zhuang, Xiaomei; Wang, Tao; He, Xinhua published an article in Journal of Molecular Structure. The title of the article was 《The effect of benzenesulfonamide′s side chains on their human carbonic anhydrase I/II inhibitory activities》.Category: piperidines The author mentioned the following in the article:

Benzenesulfonamides are well-known potent carbonic anhydrase inhibitors (CAIs). They are usually composed of benzenesulfonamide heads and hydrophobic side chain tails. However, hydrophobic side chain tails contribute to poor water solubility, which is a major challenge in the development of CAIs. Herein, to elaborate whether benzenesulfonamides with hydrophilic/hydrophobic tails are effective against carbonic anhydrases (CAs), 12 benzenesulfonamides containing hydrophilic tails and 16 benzenesulfonamides containing hydrophobic tails were designed and synthesized. Benzenesulfonamides with hydrophilic tails including 4b, 4c, and 5b and benzenesulfonamides with hydrophobic tails including 2e, 4b, and 4c are potent carbonic anhydrase I/II dual inhibitors whose Ki to CA I and CA II were below 10 nM, and below 50 nM, resp. However, the water solubility of 4b, 4c, and 5b was 52, 148, and 71 mg/100 g of water, resp., which is much better than that of benzenesulfonamides with hydrophobic tails. In a hypoxic mouse model, compounds 4c and 5b extended the survival of mice by 34.46% and 28.23%, resp., compared to the blank control. Treatment with 4c and 5b extended survival better than acetazolamide treatment did (16.86%). Moreover, 5b also has better anti-convulsant effect than AAZ. Mol. docking anal. demonstrated that hydrogen bonds between the oxygen atoms in the hydrophilic tails of 4b, 4c, and 5b and H2O in hCA I and hCA II protein facilitated ligand-receptor binding. Therefore, considering the good water solubility and potent CA I/II inhibition, 4c and 5b are worth exploring as therapeutic options for acute mountain sickness. In conclusion, benzenesulfonamides containing hydrophilic tails could offer innovative opportunities for potent, water-soluble anti-AMS (Acute Mountain Sickness) compounds In addition to this study using 2-(Piperidin-4-yl)ethanol, there are many other studies that have used 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Category: piperidines) was used in this study.

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2022,Zeng, Minghao; Liu, Wenqi; Guo, Haikun; Li, Tingting; Li, Qijia; Zhao, Chengji; Li, Xiaojin; Li, Haolong published an article in ACS Applied Energy Materials. The title of the article was 《Polyoxometalate-Cross-Linked Proton Exchange Membranes with Post-Assembled Nanostructures for High-Temperature Proton Conduction》.Safety of 1-Methyl-4-piperidone The author mentioned the following in the article:

High-temperature proton exchange membranes (HT-PEMs) are key components in high-temperature energy storage and conversion technologies, which require excellent proton conductivity and mech. strength. However, it is difficult for HT-PEMs to balance their mech. and conductive properties. Here, we present a strategy to prepare HT-PEMs based on the combination of polyoxometalate (POM)-dominated noncovalent crosslinking and H3PO4 (PA)-induced post-assembly. Hybrid membranes containing polyvinylpyrrolidone (PVP), poly(terphenyl piperidine) (PTP), and H3PW12O40 (PW) are prepared, where the polymers are electrostatically cross-linked by PW and maintain certain mobility. When the membranes adsorb PA, the polarity difference between the PVP-PW-PA moieties and the PTP-PW-PA moieties increases, causing the chains to rearrange into bicontinuous structures via a post-assembly process. The resultant membranes show a break strength over 7 MPa and a proton conductivity of ~55 mS cm-1 at 160°C. The high-temperature supercapacitors based on such membranes exhibit a specific capacitance of 145.4 F g-1 and a capacitance retention of 80% after 3000 charge-discharge cycles at 150°C. Their H2/air fuel cells display a peak power of 273.6 mW cm-2 at 160°C. This work provides a paradigm for using POMs as dynamic cross-linkers to fabricate nanostructured PEMs, which paves a feasible route to developing high-performance electrolyte materials. The experimental process involved the reaction of 1-Methyl-4-piperidone(cas: 1445-73-4Safety of 1-Methyl-4-piperidone)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Safety of 1-Methyl-4-piperidone

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

《Structure activity relationship analysis of antiproliferative cyclic C5-curcuminoids without DNA binding: Design, synthesis, lipophilicity and biological activity》 was published in Journal of Molecular Structure in 2020. These research results belong to Huber, Imre; Rozmer, Zsuzsanna; Gyongyi, Zoltan; Budan, Ferenc; Horvath, Peter; Kiss, Eszter; Perjesi, Pal. Product Details of 1445-73-4 The article mentions the following:

The chem. susceptibility of the β-diketone linker between the two aromatic rings in the structure of curcumin to hydrolysis and metabolism has made it crucial to investigate structurally modified analogs of curcumin without such shortcomings. The synthesis of twenty cyclic C5-curcuminoids, I (R = NO2, Cl, H, MeO, NMe2, X = CHMe, NH, NMe, CHOH), is described in this study in order to gain more insight into their anticancer structure-activity relationship (SAR). The design of their synthesis included four different cyclanones and five substituted aromatic aldehydes to form four, five-membered subgroups. These model compounds were evaluated in vitro for antiproliferative activity in an XTT cell viability assay against MCF-7 human non-invasive breast adenocarcinoma cancer cells and Jurkat human T lymphocyte leukemia cells in five different concentrations (10 nM, 100 nM, 1μM, 10μM and 20μM). The majority of the compounds investigated have shown remarkable cytotoxicity with IC50 values in the range of 120 nM and 2μM with very high relative toxicity values to curcumin. The SAR conclusions are drawn and summarized. A method was developed and applied in a TLC based exptl. logP measurement, which is new for such C5-curcuminoids. The logP data and structural modifications have shown a strong correlation. The correlation of these exptl. logP and the corresponding IC50 values of the model-compounds were calculated according to the Pearson and Kendall correlation coefficient and showed weak concordance. The physicochem. behaviors of the majority of these compounds are in good accordance with Lipinski’s rule. The most promising compound is I (R = NO2, X = NH), which is the most active (IC50 = 0.12-0.32μM) and most potent (80 times of curcumin) compound with the lowest lipophilicity (exptl. logP = 3.22), which is important also from a pharmacokinetic point of view. The anal. of exptl. logP and computed ClogP values have revealed good agreement. These cyclic C5-curcuminoids in contrast to curcumin do not bind to natural DNA based on their CD spectra. The results came from multiple reactions, including the reaction of 1-Methyl-4-piperidone(cas: 1445-73-4Product Details of 1445-73-4)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Product Details of 1445-73-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2019,ACS Central Science included an article by Lee, Kin Sing Stephen; Yang, Jun; Niu, Jun; Ng, Connie J.; Wagner, Karen M.; Dong, Hua; Kodani, Sean D.; Wan, Debin; Morisseau, Christophe; Hammock, Bruce D.. Electric Literature of C10H20N2O2. The article was titled 《Drug-Target Residence Time Affects in Vivo Target Occupancy through Multiple Pathways》. The information in the text is summarized as follows:

The drug discovery and development process is greatly hampered by difficulties in translating in vitro potency to in vivo efficacy. Recent studies suggest that the long-neglected drug-target residence time parameter complements classical drug affinity parameters (KI, Kd, IC50, or EC50) and is a better predictor of in vivo efficacy. Compounds with a long drug-target residence time are often more efficacious in vivo. The impact, however, of the drug-target residence time on in vivo efficacy remains controversial due to difficulties in exptl. determining the in vivo target occupancy during drug treatment. To tackle this problem, an in vivo displacement assay was developed using soluble epoxide hydrolase as a biol. model. In this report, we exptl. demonstrated that drug-target residence time affects the duration of in vivo drug-target binding. In addition, the drug-target residence time plays an important role in modulating the rate of drug metabolism which also affects the efficacy of the drug. In the experimental materials used by the author, we found tert-Butyl 4-aminopiperidine-1-carboxylate(cas: 87120-72-7Electric Literature of C10H20N2O2)

tert-Butyl 4-aminopiperidine-1-carboxylate(cas: 87120-72-7) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Electric Literature of C10H20N2O2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2018,Demuth, Jiri; Kucera, Radim; Kopecky, Kamil; Havlinova, Zuzana; Libra, Antonin; Novakova, Veronika; Miletin, Miroslav; Zimcik, Petr published 《Efficient synthesis of a wide-range absorbing azaphthalocyanine dark quencher and its application to dual-labeled oligonucleotide probes for quantitative real-time polymerase chain reactions》.Chemistry – A European Journal published the findings.Category: piperidines The information in the text is summarized as follows:

Unsym. dialkylamino-substituted zinc azaphthalocyanine (AzaPc) exhibits unique spectral and photophys. properties for dark quenchers of fluorescence in DNA hybridization probes. The panchromatic light absorption of AzaPc from 300 nm up to at least 700 nm and its lack of fluorescence make it an ideal candidate for a universal dark quencher. To prove this exptl., oligodeoxyribonucleotide probes were labeled at the 3′-end by this AzaPc and at the 5′-end by a fluorophore used in the polymerase chain reaction (PCR)-i.e., fluorescein, CAL Fluor Red 610, and Cy5. AzaPc showed a significantly higher quenching efficiency compared to the com. available dark quenchers (BHQ-1, BHQ-2, BBQ-650) in a developed model of TaqMan PCR assay. The AzaPc-labeled probe proved to also be useful in a practical PCR assay for the quantification of the SLCO2B1 transporter gene expression. The constructed calibration curves indicated linearity in the range from 102 to 107 of target copies. After reading the article, we found that the author used 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Category: piperidines)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem