Category: 85721-33-1

Biological Effect Evaluation of Different Sized Titanium Dioxide Nanoparticles Using Bombyx mori (Silkworm) as a Model Animal was written by Fometu, Sandra Senyo;Ma, Qiang;Wang, JinJin;Guo, Jianjun;Ma, Lin;Wu, Guohua. And the article was included in Biological Trace Element Research in 2022.Product Details of 85721-33-1 This article mentions the following:

Titanium dioxide nanoparticles (TiO₂ NPs) are widely used in various disciplines, and it is imperative to evaluate their safety in the environment. In this paper, Bombyx mori (silkworm) was used as a model organism to evaluate the biol. effects of different sized TiO₂ NPs, taking into consideration their effect on the larval growth, cocoon shell weight, tissues, and silk produced. The effect of the different sized TiO₂ NPs on the larval and cocoon shell weight was dose-dependent. The highest accumulation of titanium (Ti) following a modified TiO₂ NPs-treated mulberry diet was observed in the midgut. The expression of the light chain fibroin (FIBL) was three times higher in 0.33 g TiO₂ NPs-treated silk gland after 96 h. X-ray diffraction (XRD) and Fourier transform IR (FTIR) anal. demonstrated that TiO₂ NPs-treated silk fiber (TiSF) exhibited a diminutive decrease in silk fiber (SF) crystallization and β-sheet compared to the control SF, resp. The tensile tests of SF from silkworm fed with 0.03 g of 25 nm TiO₂ NPs were significantly improved when compared to the control SF. Significant changes in the surface morphol. and thermal stability of SF were observed The antimicrobial activity of TiSF was investigated against Pseudomonas aeruginosa and Staphylococcus aureus, with ciprofloxacin-treated SF acting as a control. It was documented that 0.09 g of 60 nm TiSF was most effective against P. aeruginosa at a zone of inhibition (ZOI) of 21.06 mm when compared with the control SF which recorded a ZOI of 17.19 mm. This study highlighted a different approach in evaluating the biol. effects of TiO₂ NPs using the silkworm as a model and assessing their impact on the silk intrinsic property, which will be effective in biotechnol. applications. In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 85721-33-1Product Details of 85721-33-1).

1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 85721-33-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Product Details of 85721-33-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Visible light activated MoS₂/ZnO composites for photocatalytic degradation of ciprofloxacin antibiotic and hydrogen production was written by Hunge, Y. M.;Yadav, A. A.;Kang, Seok-Won;Jun Lim, Sung;Kim, Hyunmin. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2023.Formula: C17H18FN3O3 This article mentions the following:

In the photocatalysis process, photon energy is mainly converted into chem. energy with the help of both light and catalyst. This process can be used in different applications like photocatalytic degradation of hazardous compounds, fixation of nitrogen, hydrogen production, air purification, water splitting, carbon dioxide reduction etc. In this research work, multiplicative ZnO and MoS₂/ZnO (MZ) composites were synthesized using green chem. methods like the hydrothermal process and used in two different applications i) photocatalytic degradation of ciprofloxacin (CIP) antibiotic and ii) hydrogen production CIP is not easily biodegradable and is mainly used in various antibacterial treatments. The photocatalytic activity was tested for ZnO and different MoS₂/ZnO composites along with this the effect of different amounts of catalysts doses was studied. MoS₂/ZnO composites exhibit superior photocatalytic performance than ZnO for photocatalytic degradation of CIP. Using the LC-MS technique possible degradation pathways are proposed. The same photocatalyst materials were used to test the photocatalytic H2 production activity. H₂ production rates were found to be 22, 39 and 235 μmol/g/h for ZnO, MoS₂ and MZ-30 composite resp. Superior photocatalytic activity of MZ-30 composite than ZnO is chiefly attributed to the extended light absorption capacity, effective charge transfer, suitable band alignment between the ZnO and MoS₂, min. recombination of charge carriers etc. In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 85721-33-1Formula: C17H18FN3O3).

1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 85721-33-1) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Formula: C17H18FN3O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

A single-cell nanocoating of probiotics for enhanced amelioration of antibiotic-associated diarrhea was written by Pan, Jiezhou;Gong, Guidong;Wang, Qin;Shang, Jiaojiao;He, Yunxiang;Catania, Chelsea;Dan, Birnbaum;Li, Yifei;Jia, Zhijun;Zhang, Yaoyao;Joshi, Neel S.;Guo, Junling. And the article was included in Nature Communications in 2022.Computed Properties of C17H18FN3O3 This article mentions the following:

The gut microbiota represents a large community of microorganisms that play an important role in immune regulation and maintenance of homeostasis. Living bacteria receive increasing interest as potential therapeutics for gut disorders, because they inhibit the colonization of pathogens and pos. regulate the composition of bacteria in gut. However, these treatments are often accompanied by antibiotic administration targeting pathogens. In these cases, the efficacy of therapeutic bacteria is compromised by their susceptibility to antibiotics. Here, we demonstrate that a single-cell coating composed of tannic acids and ferric ions, referred to as nanoarmor, can protect bacteria from the action of antibiotics. The nanoarmor protects both Gram-pos. and Gram-neg. bacteria against six clin. relevant antibiotics. The multiple interactions between the nanoarmor and antibiotic mols. allow the antibiotics to be effectively absorbed onto the nanoarmor. Armored probiotics have shown the ability to colonize inside the gastrointestinal tracts of levofloxacin-treated rats, which significantly reduced antibiotic-associated diarrhea (AAD) resulting from the levofloxacin-treatment and improved some of the pre-inflammatory symptoms caused by AAD. This nanoarmor strategy represents a robust platform to enhance the potency of therapeutic bacteria in the gastrointestinal tracts of patients receiving antibiotics and to avoid the neg. effects of antibiotics in the gastrointestinal tract. In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 85721-33-1Computed Properties of C17H18FN3O3).

1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 85721-33-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Computed Properties of C17H18FN3O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics