Month: November 2022

Miller, Shelli A. published the artcileProbing the Effect of Counterions on the Oxidation of Alcohols Using Oxoammonium Salts, Computed Properties of 219543-09-6, the publication is European Journal of Organic Chemistry (2020), 2020(1), 108-112, database is CAplus.

The effect of varying the counterion in the oxoammonium salt mediated oxidation of alcs. has been probed. Computational and exptl. results suggest that the counterion is non-innocent in oxoammonium salt mediated oxidations and the outcome of the reaction is related, at least in part, to the ability of the hydrogen-bond accepting nature of the anion.

European Journal of Organic Chemistry published new progress about 219543-09-6. 219543-09-6 belongs to piperidines, auxiliary class Piperidine,Fluoride,Salt,Amine,Amide, name is 4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate, and the molecular formula is C11H21BF4N2O2, Computed Properties of 219543-09-6.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Patra, Biswa R. published the artcileSlow pyrolysis of agro-food wastes and physicochemical characterization of biofuel products, HPLC of Formula: 826-36-8, the publication is Chemosphere (2021), 131431, database is CAplus and MEDLINE.

Effective management and utilization of food waste and agricultural crop residues are highly crucial to mitigate the challenges of greenhouse gas generation upon natural decomposition and waste accumulation. Conversion of biogenic wastes to biofuels and bioproducts can address the energy crisis and promote environmental remediation. This study was focused on exploring the characteristics of food waste and agricultural crop residues (e.g., canola hull and oar hull) to determine their candidacy for slow pyrolysis to produce biochar and bio-oil. Process parameters of slow pyrolysis such as temperature, reaction time and heating rate were optimized to obtain maximum biochar yields. Maximum biochar yield of 28.4 wt% was recorded at optimized temperature, heating rate and reaction time of 600°C, 5°C/min and 60 min, resp. Furthermore, the physicochem., spectroscopic and microscopic characterization of biochar, bio-oil and gases were performed. The carbon content and thermal stability of biochar were found to increase at higher temperatures Moreover, bio-oil generated at higher temperatures showed the presence of phenolics and aromatic compounds

Chemosphere published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, HPLC of Formula: 826-36-8.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Bellale, Eknath published the artcileDiarylthiazole: an antimycobacterial scaffold potentially targeting PrrB-PrrA two-component system, Name: Piperidine-4-carboxamide, the publication is Journal of Medicinal Chemistry (2014), 57(15), 6572-6582, database is CAplus and MEDLINE.

Diarylthiazole (DAT), a hit from diversity screening, was found to have potent antimycobacterial activity against Mycobacterium tuberculosis (Mtb). In a systematic medicinal chem. exploration, the authors demonstrated chem. opportunities to optimize the potency and physicochem. properties. The effort led to more than 10 compounds with submicromolar MICs and desirable physicochem. properties. The potent antimycobacterial activity, in conjunction with low mol. weight, made the series an attractive lead (antibacterial ligand efficiency (ALE) >0.4). The series exhibited excellent bactericidal activity and was active against drug-sensitive and resistant Mtb. Mutational anal. showed that mutations in prrB impart resistance to DAT compounds but not to reference drugs tested. The sensor kinase PrrB belongs to the PrrBA two component system and is potentially the target for DAT. PrrBA is a conserved, essential regulatory mechanism in Mtb and has been shown to have a role in virulence and metabolic adaptation to stress. Hence, DATs provide an opportunity to understand a completely new target system for antimycobacterial drug discovery.

Journal of Medicinal Chemistry published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, Name: Piperidine-4-carboxamide.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Xue, Wenwen published the artcilePost-polymerization modification of polymeric active esters towards TEMPO containing polymers: a systematic study, Quality Control of 826-36-8, the publication is European Polymer Journal (2020), 109660, database is CAplus.

Organic radical batteries (ORB) are a novel promising class for energy storage, particularly featuring a fast charging capability and extraordinary cycle life. The representative polymer, i.e. poly(2,2,6,6-tetramethylpiperidinyloxy-4-yl methacrylate) (PTMA), is usually synthesized by a post-polymerization oxidation method. As an alternate strategy for developing TEMPO-containing polymers, we focused on the post-polymerization modification of poly(pentafluorophenyl acrylate) and poly(pentafluorophenyl methacrylate) with three different TEMPO nucleophiles by transesterification or amidation reactions. Optimizing the conditions of the post-polymerization functionalization reaction by varying different parameters, such as the type of nucleophile, catalyst and solvent, the feeding ratios of catalysts and nucleophiles, along with reaction time and temperatures, resulted in structurally distinct TEMPO containing polymers with varying backbone composition Intriguingly, poly(2,2,6,6-tetramethylpiperidinyloxy-4-yl acrylamide) revealed the highest degree functionalization with TEMPO (96.2%) within 3 h. under considerably mild conditions, while poly(2,2,6,6-tetramethylpiperidinyloxy-4-yl methylmethacrylamide) exhibited the lowest TEMPO content owing to the steric hindrance from Me group on both the methacrylate chain and the TEMPO derivative All other four TEMPO containing polymers had a radical content similar to PTMA (66.6%) synthesized by the post-oxidation methodol. Noteworthy, compared to TEA (trimethylamine), DMAP (4-dimethylaminopyridine) facilitated an efficient ester bond cleavage independent of the polymer precursor, thus, side reactions such as hydrolysis were increased. Though hydrolysis side reaction occurred, the resulting carboxylic acid group was proven to accelerate ion transfer in a certain way during the redox process. Furthermore, due to the higher TEMPO content, poly(2,2,6,6-tetramethylpiperidinyloxy-4-yl acrylamide) exhibited a 12-22 mAh/g higher specific capacity compared to the PTMA-oxidation when running at 5C for 500 cycles.

European Polymer Journal published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C23H43NP2, Quality Control of 826-36-8.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Neuwald, Isabelle published the artcileFilling the knowledge gap: A suspect screening study for 1310 potentially persistent and mobile chemicals with SFC- and HILIC-HRMS in two German river systems, Name: 2,2,6,6-Tetramethylpiperidin-4-one, the publication is Water Research (2021), 117645, database is CAplus and MEDLINE.

Persistent and mobile chems. (PM chems.) were searched for in surface waters by hydrophilic interaction liquid chromatog. (HILIC) and supercritical fluid chromatog. (SFC), both coupled to high resolution mass spectrometry (HRMS). A suspect screening was performed using a newly compiled list of 1310 potential PM chems. to the data of 11 surface water samples from two river systems. In total, 64 compounds were identified by this approach. The overlap between HILIC- and SFC-HRMS was limited (31 compounds), confirming the complementarity of the two methods used. The identified PM candidates are characterized by a high polarity (median logD -0.4 at pH 7.5), a low mol. weight (median 187 g/mol), are mostly ionic (54 compounds) and contain a large number of heteroatoms (one per four carbons on average). Among the most frequently detected novel or yet scarcely investigated water contaminants were cyanoguanidine (11/11 samples), adamantan-1-amine (10/11), trifluoromethanesulfonate (9/11), 2-acrylamido-2-methylpropanesulfonate (10/11), and the inorganic anions hexafluorophosphate (11/11) and tetrafluoroborate (10/11). 31% of the identified suspects are mainly used in ionic liquids, a chem. diverse group of industrial chems. with numerous applications that is so far rarely studied for their occurrence in the environment. Prioritization of the findings of PM candidates is hampered by the apparent lack of toxicity data. Hence, precautionary principles and minimization approaches should be applied for the risk assessment and risk management of these substances. The large share of novel water contaminants among these findings of the suspect screening indicates that the universe of PM chems. present in the environment has so far only scarcely been explored. Dedicated anal. methods and screening lists appear essential to close the anal. gap for PM compounds

Water Research published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, Name: 2,2,6,6-Tetramethylpiperidin-4-one.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Kim, Myeong Jin published the artcileOxoammonium salt-mediated oxidative nitriles synthesis from aldehydes with ammonium acetate, Quality Control of 219543-09-6, the publication is Tetrahedron Letters (2017), 58(50), 4695-4698, database is CAplus.

An efficient and scalable route for the synthesis of nitriles I [R = n-heptyl, cyclohexyl, 4-MeOC₆H₄, 2-thienyl, etc.] was developed by oxoammonium salt (4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate) mediated oxidative conversion of aldehydes with ammonium acetate (NH₄OAc). A variety of aliphatic aldehydes as well as benzaldehydes were converted into the corresponding nitriles in high yields. The nitroxyl radical which was the reduced species of the used oxoammonium salt was recovered by simple acid-base extraction for the recycling.

Tetrahedron Letters published new progress about 219543-09-6. 219543-09-6 belongs to piperidines, auxiliary class Piperidine,Fluoride,Salt,Amine,Amide, name is 4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate, and the molecular formula is C11H21BF4N2O2, Quality Control of 219543-09-6.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Abdel-Ghaffar, S. A. published the artcileSynthesis and antimicrobial activity of some new benzenesulphonylglycine derivatives, Quality Control of 13444-24-1, the publication is Ultra Scientist of Physical Sciences (1999), 11(2), 115-121, database is CAplus.

Reaction of benzenesulfonylglycine with PCl₅ yielded the acid chloride which was reacted with amines, sulfa drugs and alcs. to give amides and esters. Condensation of PhSO₂NHCH₂CONHNH₂ with different aromatic aldehydes gave the Schiff’s bases. PhSO₂NHCH₂CON₃ was prepared by the reaction of sodium azide with PhSO₂NHCH₂COCl. Heating PhSO₂NHCH₂CON₃ in benzene, followed by condensation with amines or alcs. afforded urea and carbamate derivatives All the synthesized compound have been tested against a number of microorganisms. The amides possessed high activity against Bacillus subtilis, whereas the other compounds were inactive. The esters showed promising activity against several organisms.

Ultra Scientist of Physical Sciences published new progress about 13444-24-1. 13444-24-1 belongs to piperidines, auxiliary class Piperidine,Alcohol, name is 1-Ethylpiperidin-3-ol, and the molecular formula is C7H15NO, Quality Control of 13444-24-1.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Powell, Jonathan published the artcileSmall Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells, Computed Properties of 39546-32-2, the publication is Journal of Medicinal Chemistry (2018), 61(9), 4135-4154, database is CAplus and MEDLINE.

We report the design, synthesis and comprehensive biol. evaluation of a range of some potent small-mol. neuropilin-1 (NRP1) antagonists. NRP1 is implicated in the immune response to tumors, particularly in Treg cell fragility, required for PD1 checkpoint blockade. The design of these compounds was based on a previously identified compound EG00229 which was used a starting point for optimization. Through targeting of specific amino-acid residues addnl. H-bonding interactions were introduced, which led to increases in binding affinity and potency. The design of these mols. was informed and supported by X-ray crystal structures. Pharmacokinetic data was obtained for some of the most potent compounds, and compound 1 (EG01377) was identified as having properties suitable for further investigation. Compound 1 was then tested in several in vitro assays, and was shown to have anti-angiogenic, anti-migratory and anti-tumor effects. Remarkably, 1 was shown to be selective for NRP1 over the closely related protein NRP2. In purified Nrp1+, FoxP3+, CD25+ populations of Tregs from mice 1 was able to block a glioma conditioned medium induced increase in TGFβ production This study therefore represents a comprehensive characterization of a small-mol. NRP1 antagonist, and provides the basis for future in vivo studies.

Journal of Medicinal Chemistry published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, Computed Properties of 39546-32-2.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Vuong, Wayne published the artcileSynthesis of Chiral Spin-Labeled Amino Acids, Application of 2,2,6,6-Tetramethylpiperidin-4-one, the publication is Organic Letters (2019), 21(24), 10149-10153, database is CAplus and MEDLINE.

Spin-labeled amino acids (SLAAs) are often used to determine intermol. distances and conformations in proteins via double electron-electron resonance. Currently available SLAAs can be difficult to incorporate selectively and have little resemblance to natural side chains in proteins. Enantioselective synthesis of three spin-labeled L-amino acids is described, starting from readily available 2,2,6,6-tetramethyl-4-piperidinone. These SLAAs better replicate canonical residues in proteins and aim for biol. incorporation via genetic incorporation or solid-phase peptide synthesis.

Organic Letters published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C19H21N3O3S, Application of 2,2,6,6-Tetramethylpiperidin-4-one.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Bogolubsky, Andrey V. published the artcileBis(2,2,2-trifluoroethyl) Carbonate as a Condensing Agent in One-Pot Parallel Synthesis of Unsymmetrical Aliphatic Ureas, Name: Piperidine-4-carboxamide, the publication is ACS Combinatorial Science (2014), 16(6), 303-308, database is CAplus and MEDLINE.

One-pot parallel synthesis of unsym. aliphatic ureas was achieved with bis(2,2,2-trifluoroethyl) carbonate. The procedure worked well for both the monosubstituted and functionalized alkylamines and required no special conditions (temperature control, order, or rate of addition). Thus, an acetonitrile solution of the first alkylamine, N,N-diisopropylethylamine, and bis(2,2,2-trifluoroethyl) carbonate was heated at 75 °C in a sealed tube for 2 h. After complete removal of bis(2,2,2-trifluoroethyl) carbonate and addition of DBU, the second alkylaminewas added to the crude trifluoroethyl carbamate to give the unsym. aliphatic urea. A library of 96 diverse ureas was easily synthesized.

ACS Combinatorial Science published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, Name: Piperidine-4-carboxamide.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem