Heterocyclic Building Blocks-piperidine

A magnetic nanocomposite optosensing probe based on porous graphene, selective polymer and quantum dots for the detection of cefoperazone in milk was written by Chaitong, Nuntanut;Chansud, Nutnicha;Orachorn, Naphatsakorn;Limbut, Warakorn;Bunkoed, Opas. And the article was included in Microchemical Journal in 2021.SDS of cas: 62893-19-0 This article mentions the following:

An optosensor based on synthesized magnetic composite sensing probes was designed to detect ultra-trace levels of cefoperazone. The nanocomposite probe integrated porous graphene, quantum dots, magnetite nanoparticles and highly specific polymer. These substances produced an ultra-sensitive, selective and rapid sensor. The fluorescence emission of the nanoprobes was quenched when cefoperazone interacted with the imprinted binding sites. The developed probe exhibited good linearity toward cefoperazone from 0.10 to 25.0μg L-1 and the limit of detection was 0.09μg L-1. The fabricated magnetic nanocomposite sensor showed good specificity for cefoperazone with an imprinting factor of 7.5 and was not interfered by the analog structures ceftriaxone, cefazolin, cefradine, ceftazidime and cefalexin. The nanocomposite probe successfully detected cefoperazone in milk. Recoveries ranged from 85.3 to 98.3% with RSDs < 6%. Anal. results agreed well with HPLC but the advantages of the optosensor include a simple, rapid procedure, cost-effective equipment and environmental friendliness. In the experiment, the researchers used many compounds, for example, (6R,7R)-7-((R)-2-(4-Ethyl-2,3-dioxopiperazine-1-carboxamido)-2-(4-hydroxyphenyl)acetamido)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (cas: 62893-19-0SDS of cas: 62893-19-0).

(6R,7R)-7-((R)-2-(4-Ethyl-2,3-dioxopiperazine-1-carboxamido)-2-(4-hydroxyphenyl)acetamido)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (cas: 62893-19-0) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.SDS of cas: 62893-19-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

An ultra-sensitive rifampicin electrochemical sensor based on Fe₃O₄ nanoparticles anchored Multiwalled Carbon nanotube modified glassy carbon electrode was written by Alizadeh, Marzie;Asrami, Padideh Naderi;Altuner, Elif Esra;Gulbagca, Fulya;Tiri, Rima Nour Elhouda;Aygun, Aysenur;Kaynak, Idris;Sen, Fatih;Cheraghi, Somaye. And the article was included in Chemosphere in 2022.Category: piperazines This article mentions the following:

This study aimed to guide future sensor studies against other pharmaceutical drugs by synthesizing Fe3O4NPs@MWCNT metallic nanoparticles (NPs). Side damage caused by excessive accumulation of tuberculosis drugs in the body can cause clots in the organs, and cause serious damage such as heart attack and respiratory failure, and threaten human life. Therefore, the development of sensors sensitive to various antibiotics in this study is important for human health. In this study, the sensitivity of Fe3O4 NPs to tuberculosis drug (rifampicin) was evaluated by catalytic reaction using bare/GCE, MWCNT/GCE, and Fe3O4NPs@MWCNT/GCE electrodes. First of all, Fe3O4 NPs were successfully synthesized for the study and MWCNT/GCE and Fe3O4 NPs@MWCNT/GCE electrodes were formed with the modification of the MWCNT support material. It was observed that the Fe3O4 NPs@MWCNT/GCE electrode gave the highest signal against the other electrodes. The morphol. structure of Fe3O4 NPs was determined by various characterization techniques such as Transmission Electron Microscopy (TEM), Fourier Transmission IR Spectroscopy (FTIR), UV-visible (UV-Vis), and X-ray differential (XRD) and the obtained NPs were used for sensor studies, and it was observed that the current intensity increased as the scanning speed of each electrode increased in CV and DPV measurements. The average size of Fe3O4 NPs was found to be 7.32 ± 3.2 nm. Anodic current peaks occurred in the linear range of 2-25 μM. According to the results obtained from the measurements, the limit of detection (LOD) value was calculated as 0.64 μM limit of quantification (LOQ) 1.92 μM. In the experiment, the researchers used many compounds, for example, 8-(n-(4-methyl-1-piperazinyl)formidoyl)-rifomycins (cas: 13292-46-1Category: piperazines).

8-(n-(4-methyl-1-piperazinyl)formidoyl)-rifomycins (cas: 13292-46-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Trends and correlation between antibacterial consumption and carbapenem resistance in gram-negative bacteria in a tertiary hospital in China from 2012 to 2019 was written by Liang, Chunhong;Zhang, Xueyan;Zhou, Lijuan;Meng, Guangyi;Zhong, Liqiu;Peng, Pingzhi. And the article was included in BMC Infectious Diseases in 2021.Category: piperazines This article mentions the following:

To investigate the trends and correlation between antibacterial consumption and carbapenem resistance in Gram-neg. bacteria from 2012 to 2019 in a tertiary-care teaching hospital in southern China. This retrospective study included data from hospital-wide inpatients collected between Jan. 2012 and Dec. 2019. Data on antibacterial consumption were expressed as defined daily doses (DDDs)/1000 patient-days. Antibacterials were classified according to the Anatomical Therapeutic Chem. (ATC) classification system. The trends in antimicrobial usage and resistance were analyzed by linear regression, while Pearson correlation anal. was used for assessing correlations. An increasing trend in the annual consumption of tetracyclines, β-lactam/β-lactamase inhibitor (BL/BLI) combinations, and carbapenems was observed (P < 0.05). Carbapenem resistance in Acinetobacter baumannii (A. baumannii) significantly increased (P < 0.05) from 18% in 2012 to 60% in 2019. Moreover, significant pos. correlations were found between resistance to carbapenems in A. baumannii (P < 0.05) and Escherichia coli (E. coli; P < 0.05) and consumption of carbapenems, while the resistance rate of A. baumannii to carbapenems was pos. correlated with cephalosporin/β-lactamase inhibitor (C/BLI) combinations (P < 0.01) and tetracyclines usage (P < 0.05). We also found that use of quinolones was pos. correlated with the resistance rate of Burkholderia cepacia (B. cepacia) to carbapenems (P < 0.05), and increasing uses of carbapenems (P < 0.01) and penicillin/β-Lactamase inhibitor (P/BLI) combinations (P < 0.01) were significantly correlated with reduced resistance of Enterobacter cloacae (E. cloacae) to carbapenems. Conclusion: These results revealed significant correlations between consumption of antibiotics and carbapenem resistance rates in Gram-neg. bacteria. Implementing proper management strategies and reducing the unreasonable use of antibacterial drugs may be an effective measure to reduce the spread of carbapenem-resistant Gram-neg. bacteria (CRGN), which should be confirmed by further studies. In the experiment, the researchers used many compounds, for example, (6R,7R)-7-((R)-2-(4-Ethyl-2,3-dioxopiperazine-1-carboxamido)-2-(4-hydroxyphenyl)acetamido)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (cas: 62893-19-0Category: piperazines).

(6R,7R)-7-((R)-2-(4-Ethyl-2,3-dioxopiperazine-1-carboxamido)-2-(4-hydroxyphenyl)acetamido)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (cas: 62893-19-0) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Analytical Approaches in Official Food Safety Control: An LC-Orbitrap-HRMS Screening Method for the Multiresidue Determination of Antibiotics in Cow, Sheep, and Goat Milk was written by Salis, Severyn;Rubattu, Nicola;Rubattu, Federica;Cossu, Maurizio;Sanna, Andrea;Chessa, Giannina. And the article was included in Molecules in 2022.Recommanded Product: 98105-99-8 This article mentions the following:

The presence of unauthorized substances, such as residues of veterinary medicines or chem. contaminants, in food can represent a possible health concern. For this reason, a complete legislative framework has been established in the European Union (EU), which defines the maximum limits allowed in food and carries out surveillance programs to control the presence of these substances. Official food control laboratories, in order to ensure a high level of consumer protection, must respond to the challenge of improving and harmonizing the performance of the anal. methods used for the anal. of residues of authorized, unauthorized, or prohibited pharmacol. active substances. Laboratories must also consider the state of the art of the anal. methodologies and the performance requirements of current legislation. The aim of this work was to develop a multiresidue method for the determination of antibiotics in milk, compliant with the criteria and procedures established by Commission Implementing Regulation (EU) 2021/808. The method uses an LC-Orbitrap-HRMS for the determination of 57 mols. of antibiotic and active antibacterial substances belonging to different chem. classes (beta-lactams, tetracyclines, sulfonamides, quinolones, pleuromutilins, macrolides, and lincosamides) in bovine, ovine, and goat milk samples. It provides a simple and quick sample pretreatment and a subsequent identification phase of analytes, at concentrations equal to or lower than the maximum residual limit (MRL), in compliance with Commission Regulation (EU) 2010/37. The validation parameters: selectivity, stability, applicability, and detection capability (ccβ), are in agreement with the requirements of Commission Implementing Regulation (EU) 2021/808 and demonstrated the effectiveness of the method in detecting veterinary drug residues at the target screening concentration (at the MRL level or below), with a false pos. rate of less than 5%. This method represents an effective solution for detecting antibiotics in milk, which can be successfully applied in routine analyses for official food control plans. In the experiment, the researchers used many compounds, for example, 6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 98105-99-8Recommanded Product: 98105-99-8).

6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 98105-99-8) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Recommanded Product: 98105-99-8

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists. 2. Synthesis, Chirality, and Pharmacokinetics was written by Borthwick, Alan D.;Davies, Dave E.;Exall, Anne M.;Livermore, David G.;Sollis, Steve L.;Nerozzi, Fabrizio;Allen, Michael J.;Perren, Marion;Shabbir, Shalia S.;Woollard, Patrick M.;Wyatt, Paul G.. And the article was included in Journal of Medicinal Chemistry in 2005.SDS of cas: 27913-99-1 This article mentions the following:

A short stereoselective synthesis of a series of chiral 7-aryl-2,5-diketopiperazines oxytocin antagonists is described. Varying the functionality and substitution pattern of substituents in the 7-aryl ring and varying the chirality of this exocyclic ring have produced potent oxytocin antagonists (pK_i > 8.5). SAR and pharmacokinetic profiling of this series of (3R,6R,7R)-2,5-diketopiperazines together with the introduction of an ortho F group in the 7-aryl ring to improve rat pK has culminated in the 2′,4′-difluorophenyldiketopiperazine derivative I, a highly potent oxytocin antagonist against the human oxytocin receptor (pK_i = 8.9) that has >1000-fold selectivity over all three vasopressin receptors V1a, V2, and V1b. It has good bioavailability (46%) in the rat and moderate bioavailability (13-31%) in the dog and is more active in vivo in the rat than atosiban (rat DR₁₀ = 0.44 mg/kg iv). In the experiment, the researchers used many compounds, for example, 4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1SDS of cas: 27913-99-1).

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. SDS of cas: 27913-99-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The clinical efficacy of pulmonary hypertension-specific agents in idiopathic pulmonary fibrosis: systematic review and meta-analysis of randomized controlled clinical trials was written by Lee, Jonghoo;Song, Jae-Uk. And the article was included in Journal of Korean Medical Science in 2020.Computed Properties of C23H32N6O4S This article mentions the following:

Pulmonary hypertension (PH) is common in patients with idiopathic pulmonary fibrosis (IPF) and is associated with poor outcomes. This study was performed to determine the clin. efficacy of PH-specific therapeutic agents for IPF patients. We performed a systematic review and meta-anal. using MEDLINE, EMBASE, and the Cochrane Central Register. We searched randomized controlled trials (RCTs) without language restriction until Nov. 2018. The primary outcome was all-cause mortality to end of study. We analyzed 10 RCTs involving 2,124 patients, 1,274 of whom received PH-specific agents. In pooled estimates, the use of PH-specific agents was not significantly associated with reduced all-cause mortality to end of study compared with controls (hazard ratio, 0.99; 95% confidence interval [CI], 0.92, 1.06; P = 0.71; I2 = 30%). When we performed subgroup analyses according to the type of PH-specific agent, sample size, age, forced vital capacity, diffusion lung capacity, and the extent of honeycombing, PH-specific agents also showed no significant association with a reduction in all-cause mortality. A small but significant improvement in quality of life, measured using the St. George Respiratory Questionnaire total score, was found in the PH-specific agent group (mean difference, -3.16 points; 95% CI, -5.34, -0.97; P = 0.005; I2 = 0%). We found no significant changes from baseline in lung function, dyspnea, or exercise capacity. Serious adverse events were similar between the two groups. Although PH-specific agents provided small health-related quality-of-life benefits, our meta-anal. provides insufficient evidence to support their use in IPF patients. In the experiment, the researchers used many compounds, for example, 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4Computed Properties of C23H32N6O4S).

2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Computed Properties of C23H32N6O4S

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Piperazino biguanides as cysticidal agents was written by Sharma, M.;Shanker, K.;Nath, Renu;Bhargava, K. P.;Kishor, K.. And the article was included in Indian Journal of Pharmacy in 1977.Reference of 142-64-3 This article mentions the following:

Of 19 piperazino biguanide derivatives (I) prepared and tested for ameba cysticidal activity, II (I, R = H, X = N-Ph) [65968-12-9] was the most active. The cysticidal activities of II in concentrations of 0.5, 0.25, 0.125, 0.0625, 0.0312, and 0.0156 mg/mL were 100, 75.5, 48.0, 19.5, 9.0, and 0%, resp. Amebicidal activity was not detected in any of the 19 I derivatives In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Reference of 142-64-3).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Reference of 142-64-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Visible light activated MoS₂/ZnO composites for photocatalytic degradation of ciprofloxacin antibiotic and hydrogen production was written by Hunge, Y. M.;Yadav, A. A.;Kang, Seok-Won;Jun Lim, Sung;Kim, Hyunmin. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2023.Formula: C17H18FN3O3 This article mentions the following:

In the photocatalysis process, photon energy is mainly converted into chem. energy with the help of both light and catalyst. This process can be used in different applications like photocatalytic degradation of hazardous compounds, fixation of nitrogen, hydrogen production, air purification, water splitting, carbon dioxide reduction etc. In this research work, multiplicative ZnO and MoS₂/ZnO (MZ) composites were synthesized using green chem. methods like the hydrothermal process and used in two different applications i) photocatalytic degradation of ciprofloxacin (CIP) antibiotic and ii) hydrogen production CIP is not easily biodegradable and is mainly used in various antibacterial treatments. The photocatalytic activity was tested for ZnO and different MoS₂/ZnO composites along with this the effect of different amounts of catalysts doses was studied. MoS₂/ZnO composites exhibit superior photocatalytic performance than ZnO for photocatalytic degradation of CIP. Using the LC-MS technique possible degradation pathways are proposed. The same photocatalyst materials were used to test the photocatalytic H2 production activity. H₂ production rates were found to be 22, 39 and 235 μmol/g/h for ZnO, MoS₂ and MZ-30 composite resp. Superior photocatalytic activity of MZ-30 composite than ZnO is chiefly attributed to the extended light absorption capacity, effective charge transfer, suitable band alignment between the ZnO and MoS₂, min. recombination of charge carriers etc. In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 85721-33-1Formula: C17H18FN3O3).

1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 85721-33-1) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Formula: C17H18FN3O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Biological Effect Evaluation of Different Sized Titanium Dioxide Nanoparticles Using Bombyx mori (Silkworm) as a Model Animal was written by Fometu, Sandra Senyo;Ma, Qiang;Wang, JinJin;Guo, Jianjun;Ma, Lin;Wu, Guohua. And the article was included in Biological Trace Element Research in 2022.Product Details of 85721-33-1 This article mentions the following:

Titanium dioxide nanoparticles (TiO₂ NPs) are widely used in various disciplines, and it is imperative to evaluate their safety in the environment. In this paper, Bombyx mori (silkworm) was used as a model organism to evaluate the biol. effects of different sized TiO₂ NPs, taking into consideration their effect on the larval growth, cocoon shell weight, tissues, and silk produced. The effect of the different sized TiO₂ NPs on the larval and cocoon shell weight was dose-dependent. The highest accumulation of titanium (Ti) following a modified TiO₂ NPs-treated mulberry diet was observed in the midgut. The expression of the light chain fibroin (FIBL) was three times higher in 0.33 g TiO₂ NPs-treated silk gland after 96 h. X-ray diffraction (XRD) and Fourier transform IR (FTIR) anal. demonstrated that TiO₂ NPs-treated silk fiber (TiSF) exhibited a diminutive decrease in silk fiber (SF) crystallization and β-sheet compared to the control SF, resp. The tensile tests of SF from silkworm fed with 0.03 g of 25 nm TiO₂ NPs were significantly improved when compared to the control SF. Significant changes in the surface morphol. and thermal stability of SF were observed The antimicrobial activity of TiSF was investigated against Pseudomonas aeruginosa and Staphylococcus aureus, with ciprofloxacin-treated SF acting as a control. It was documented that 0.09 g of 60 nm TiSF was most effective against P. aeruginosa at a zone of inhibition (ZOI) of 21.06 mm when compared with the control SF which recorded a ZOI of 17.19 mm. This study highlighted a different approach in evaluating the biol. effects of TiO₂ NPs using the silkworm as a model and assessing their impact on the silk intrinsic property, which will be effective in biotechnol. applications. In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 85721-33-1Product Details of 85721-33-1).

1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 85721-33-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Product Details of 85721-33-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Anthemintic drugs. Their ovicidal and larvicidal actions was written by Goulart, Enio G.;De Arruda, Mercia E.;Jourdan, Myriam C.. And the article was included in Revista Brasileira de Medicina in 1974.Quality Control of Piperazine Dihydrochloride This article mentions the following:

Of 9 chemotherapeutic anthelmintics tested in vitro against eggs and larvae of Ascaris lumbricoides, Trichuris trichiura, and Ancylostoma caninum, pyrantel pamoate [22204-24-6] and tetrachloroethylene [127-18-4] (10 and 100 mg each) inhibited development of A. caninum; similar results were obtained with 1 mg tetramisole-HCl (I-HCl) [5086-74-8] and thiabendazole (II) [148-79-8]. Stilbazium iodide [3784-99-4], pyrvinium pamoate [3546-41-6], and bephenium hydroxynaphthoate [3818-50-6] showed anthelmintic activity which was directly related to the concentrations None of the compounds tested showed embryogenic blocking activity against A. lumbricoides or T. trichiura. Prophylactic treatments of contaminated soil or organic fertilizer are apparently ineffective. In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Quality Control of Piperazine Dihydrochloride).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Quality Control of Piperazine Dihydrochloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics