Design and Application of a DNA-Encoded Macrocyclic Peptide Library was written by Zhu, Zhengrong;Shaginian, Alex;Grady, LaShadric C.;O’Keeffe, Thomas;Shi, Xiangguo E.;Davie, Christopher P.;Simpson, Graham L.;Messer, Jeffrey A.;Evindar, Ghotas;Bream, Robert N.;Thansandote, Praew P.;Prentice, Naomi R.;Mason, Andrew M.;Pal, Sandeep. And the article was included in ACS Chemical Biology in 2018.Synthetic Route of C21H21NO4 The following contents are mentioned in the article:
A DNA-encoded macrocyclic peptide library was designed and synthesized with 2.4 × 1012 members composed of 4-20 natural and non-natural amino acids. Affinity-based selection was performed against two therapeutic targets, VHL and RSV N protein. On the basis of selection data, some peptides were selected for resynthesis without a DNA tag, and their activity was confirmed. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Synthetic Route of C21H21NO4).
(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Synthetic Route of C21H21NO4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem