Zhou, Xueying published the artcileHaloamines as Bifunctional Reagents for Oxidative Aminohalogenation of Maleimides, Application of tert-Butyl piperidin-4-ylcarbamate, the main research area is chloro amino pyrroledione green preparation; maleimide haloamine oxidative aminohalogenation copper catalyst.
An unprecedented copper-catalyzed oxidative aminohalogenation of electron-deficient maleimides with secondary amines and NXS (X = Cl, Br, I) was developed to form pyrrole-2,5-diones I [R1 = Me, R2 = n-pentyl, Bn, CH2(4-ClC6H4), etc.; R1R2 = CH2CH2CH2, CH2CH2OCH2CH2, CH2(CH2)3CH2, etc.] in which the N-X bonds generated in situ were used as difunctionalized reagents. The distinctive features of this multicomponent reaction included a simple green catalytic system, a spectral substrate range and the late-stage modification of drug mols. Most importantly, this umpolung radical cascade strategy exploits the in situ formation of N-iodoamines that enabled efficient alkene aminoiodination.
Organic Letters published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 73874-95-0 belongs to class piperidines, name is tert-Butyl piperidin-4-ylcarbamate, and the molecular formula is C10H20N2O2, Application of tert-Butyl piperidin-4-ylcarbamate.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem