UiO-type metal-organic frameworks with NHC or metal-NHC functionalities for N-methylation using CO2 as the carbon source was written by Zhang, Xu;Jiang, Yilin;Fei, Honghan. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.COA of Formula: C10H21N This article mentions the following:
The first metal-organic framework (MOF) catalyzed N-methylation of amines using 1 atm CO2 and phenylsilane under ambient conditions was reported. Compared with its homogeneous analog, the incorporation of N-heterocyclic carbene (NHC) into the MOF provided more efficient catalysis with improved reaction kinetics, turnover numbers and recyclability. Moreover, the metalated NHC functionalized MOF achieved direct N-methylation of amines bearing carboxylate moieties, which were common building blocks in pharmaceutical chem. In the experiment, the researchers used many compounds, for example, 1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0COA of Formula: C10H21N).
1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.COA of Formula: C10H21N
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem