CuI/N4 ligand/TEMPO derivatives: a mild and highly efficient system for aerobic oxidation of primary alcohols was written by Zhang, Shufang;Miao, Chengxia;Xu, Daqian;Sun, Wei;Xia, Chungu. And the article was included in Cuihua Xuebao in 2014.Quality Control of 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl This article mentions the following:
A new system consisting of a copper(I) complex generated in situ from a tetradentate nitrogen ligand and CuI in combination with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) derivatives was successfully developed. The system was suitable for efficient and selective aerobic oxidation of primary benzyl and allyl alcs. with a wide range of functional groups to the corresponding aldehydes at room temperature The best result was obtained with N,N’-dimethyl-N,N’-bis(2-pyridylmethyl)ethane-1,2-diamine as the ligand and 4-OH-TEMPO as a catalyst in MeCN. In addition, high-resolution mass spectrometry, UV-visible spectroscopy, and electrochem. experiments were used to provide evidence of intermediates. In the experiment, the researchers used many compounds, for example, 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5Quality Control of 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl).
4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Quality Control of 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem