To investigate whether hematocrit affects thromboelastography parameters was written by Zhang, Min;He, Keyu;Ye, Dong;Zhang, Qiang;Zhang, Zhengkang. And the article was included in Contrast Media & Molecular Imaging in 2022.Electric Literature of C9H16NO2 This article mentions the following:
Background. Thromboelastogram (TEG) is an experiment to detect coagulation function with whole blood. Red blood cell (RBC) is the most abundant component of blood. Whether RBC has an impact on the results of thromboelastogram? Study Design and Methods. The correlation between hematocrit (HCT) and TEG was analyzed. 17 samples were reconstituted with different HCT. They were tested sep. Correction tests were performed on 17 samples from patients with anemia. HCT was corrected to 0.40 in female and 0.45 in males. The correction formula was determined according to the exptl. correction. Results. HCT was neg. correlated with TEG parameters. As HCT increased, CI and angle decreased (P < 0.05, P < 0.001) and K increased (P < 0.001) in reconstituted samples. In the correction test, the angle measured value was 69.48 卤 4.98 and corrected value was 62.48 卤 6.25, MA measured value was 61.44 卤 7.10 and corrected value was 55.94 卤 7.12, K measured value was 1.45 卤 0.48 and corrected value was 2.11 卤 0.79, and CI measured value was 1.07 卤 1.67 and corrected value was -0.45 卤 1.64. There was a significant difference. The correction formulas of anemia were derived from the exptl. correction results. KCorrection value = (0.7903*A2 – 2.1803A + 2.8268)*KMeasured value; Tan angleCorrection value = Tan angleMeasured value/(0.6596*A2 – 1.7478A + 2.4608); MACorrection value = MAMeasured value/(0.1853ln (A) + 1.0197); CICorrection value = -0.6516RMeasured value – 0.3772KCorrection value + 0.1224MACorrection value + 0.0759angleCorrection value – 7.7922. Conclusion. HCT has a neg. impact on TEG parameters. Coagulation state of anemia patients is overestimated by TEG. The test results of anemia patients need to be corrected whether through the exptl. correction or the formula correction. In the experiment, the researchers used many compounds, for example, 4-Oxo-tempo (cas: 2896-70-0Electric Literature of C9H16NO2).
4-Oxo-tempo (cas: 2896-70-0) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Electric Literature of C9H16NO2
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem