Zhang, Hua published the artcileQuantification and molecular imaging of fatty acid isomers from complex biological samples by mass spectrometry, COA of Formula: C20H22ClN3O3, the publication is Chemical Science (2021), 12(23), 8115-8122, database is CAplus and MEDLINE.
Elucidating the isomeric structure of free fatty acids (FAs) in biol. samples is essential to comprehend their biol. functions in various physiol. and pathol. processes. Herein, we report a novel approach of using peracetic acid (PAA) induced epoxidation coupled with mass spectrometry (MS) for localization of the C-C bond in unsaturated FAs, which enables both quantification and spatial visualization of FA isomers from biol. samples. Abundant diagnostic fragment ions indicative of the C-C positions were produced upon fragmentation of the FA epoxides derived from either in-solution or on-tissue PAA epoxidation of free FAs. The performance of the proposed approach was evaluated by anal. of FAs in human cell lines as well as mapping the FA isomers from cancer tissue samples with MALDI-TOF/TOF-MS. Merits of the newly developed method include high sensitivity, simplicity, high reaction efficiency, and capability of spatial characterization of FA isomers in tissue samples.
Chemical Science published new progress about 1032229-33-6. 1032229-33-6 belongs to piperidines, auxiliary class Metabolic Enzyme,SCD, name is 4-(2-Chlorophenoxy)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide, and the molecular formula is C9H21NO3, COA of Formula: C20H22ClN3O3.
Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem