In 2022,Zha, Liang; Xie, Yunfeng; Wu, Chengyao; Lei, Ming; Lu, Xueer; Tang, Wenjian; Zhang, Jing published an article in European Journal of Medicinal Chemistry. The title of the article was 《Novel benzothiazole-urea hybrids: Design, synthesis and biological activity as potent anti-bacterial agents against MRSA》.Category: piperidines The author mentioned the following in the article:
Novel benzothiazole-urea hybrids were designed, synthesized and evaluated for their anti-bacterial activity. They only exhibited anti-bacterial activity against Gram-pos. bacteria, including clin. methicillin-resistant S. aureus (MRSA), compounds I (R = 4-CF3C6H4NH, 2,4-F2C6H3NH), II (R1 = H, R2 = 4-CF3C6H4NH), II (R1 = Cl, R2 = 4-CF3C6H4NH), and II (R1 = Cl, R2 = 2,4-F2C6H3NH) exhibited potent activity (MIC = 0.39 and 0.39/0.78μM against SA and MRSA, resp.). Crystal violet assay showed that compounds I (R = 4-CF3C6H4NH) II (R1 = H, R2 = 4-CF3C6H4NH), and II (R1 = Cl, R2 = 2,4-F2C6H3NH) not only inhibited the formation of biofilms but also eradicated preformed biofilms. Compound II (R1 = Cl, R2 = 2,4-F2C6H3NH) had membrane disruption, little propensity to induce resistance, benign safety and in vivo anti-MRSA efficacy in a mouse model of abdominal infection. Therefore, authors data demonstrated the potential to advance benzothiazole-urea hybrids as a new class of antibiotics. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl 4-hydroxypiperidine-1-carboxylate(cas: 109384-19-2Category: piperidines)
tert-Butyl 4-hydroxypiperidine-1-carboxylate(cas:109384-19-2) is a 4-hydroxypyridine with a boc protecting group used in the preparation of neurologically active agents and other pharmaceutical compounds.Category: piperidines
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem