Zdarova Karasova, Jana et al. published their research in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences in 2018 | CAS: 120014-30-4

5,6-Dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydro-1H-inden-1-one (cas: 120014-30-4) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Electric Literature of C17H23NO3

1-Benzyl-4-methylpiperidinyl moiety in donepezil: The priority ticket across the blood-brain-barrier in rats was written by Zdarova Karasova, Jana;Sestak, Vit;Korabecny, Jan;Mezeiova, Eva;Palicka, Vladimir;Kuca, Kamil;Mzik, Martin. And the article was included in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences in 2018.Electric Literature of C17H23NO3 This article mentions the following:

The main aim of the authors’ study was to clarify which part of the donepezil mol. determines its ability to cross the blood-brain barrier (BBB). The authors developed and fully validated a rapid, selective and sensitive method to quantify donepezil and its three fragments in rat plasma and brain homogenate, employing ultra-HPLC with high resolution mass spectrometry (Orbitrap, Q-Exactive Focus), and used it to assess the pharmacokinetics after concomitant administration of donepezil and its three fragments. In the experiment, the researchers used many compounds, for example, 5,6-Dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydro-1H-inden-1-one (cas: 120014-30-4Electric Literature of C17H23NO3).

5,6-Dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydro-1H-inden-1-one (cas: 120014-30-4) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Electric Literature of C17H23NO3

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem