Zapol’skii, Viktor A.; Berneburg, Isabell; Bilitewski, Ursula; Dillenberger, Melissa; Becker, Katja; Jungwirth, Stefan; Shekhar, Aditya; Krueger, Bastian; Kaufmann, Dieter E. published an article in 2022, the title of the article was Chemistry of polyhalogenated nitrobutadienes, 17: efficient synthesis of persubstituted chloroquinolinyl-1H-pyrazoles and evaluation of their antimalarial, anti-SARS-CoV-2, antibacterial, and cytotoxic activities.Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol And the article contains the following content:
A series of 26 novel 1-(7-chloroquinolin-4-yl)-4-nitro-1H-pyrazoles bearing a dichloromethyl and an amino or thio moiety at C3 and C5 has been prepared in yields up to 72% from the reaction of 1,1-bisazolyl-, 1-azolyl-1-amino-, and 1-thioperchloro-2-nitrobuta-1,3-dienes with 7-chloro-4-hydrazinylquinoline. A new way for the formation of a pyrazole cycle from 3-methyl-2-(2,3,3-trichloro-1-nitroallylidene)oxazolidine is also described. In addition, the antimalarial activity of the synthesized compounds has been evaluated in vitro against the protozoan malaria parasite Plasmodium falciparum. Notably, the I and 7-chloro-4-(3-((4-chlorophenyl)thio)-5-(dichloromethyl)-4-nitro-1H-pyrazol-1-yl)quinoline inhibited the growth of the chloroquine-sensitive Plasmodium falciparum strain 3D7 with EC50 values of 0.2 ± 0.1μM (85 ng/mL, 200 nM) and 0.2 ± 0.04μM (100 ng/mL, 200 nM), resp. Two compounds (I and II) have also been tested for anti-SARS-CoV-2, antibacterial, and cytotoxic activity. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol
The Article related to persubstituted chloroquinolinyl pyrazole preparation antimalarial antisars cov2 antibacterial cytotoxic, 1h-pyrazoles, 2-nitroperchlorobutadiene, anti-sars-cov-2 activity, antimalarial activity, chloroquine, nucleophilic vinylic substitution and other aspects.Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem