《Synthesis and Anticancer Activity of New Substituted Piperidinones Linked to Pyrimidine, Thiazole, and Triazole Glycoside Derivatives》 was written by Yousif, M. N. M.; Nassar, I. F.; Yousif, N. M.; Awad, H. M.; El-Sayed, W. A.. Application In Synthesis of Triacetonamine And the article was included in Russian Journal of General Chemistry on August 31 ,2019. The article conveys some information:
New piperidinone incorporating pyrimidine, triazine, diazipine, oxatriazine, and thiazole derivatives have been synthesized starting with tetramethylpipridin-4-one. Structures of the newly synthesized compounds are characterized on the basis of spectroscopic and anal. data. The anticancer activity of the prepared compounds has been studied in vitro against HCT-116 and MCF-7 human cancer cells using the MTT assay. A number of compounds demonstrates potent activity towards both cell lines with IC50 values comparable with doxorubicin. In the experiment, the researchers used Triacetonamine(cas: 826-36-8Application In Synthesis of Triacetonamine)
Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Application In Synthesis of Triacetonamine
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem