Piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. This gave the compound its name. 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. Other examples are the fire ant toxin solenopsin, the nicotine analog anabasine of tree tobacco (Nicotiana glauca), lobeline of Indian tobacco. Application In Synthesis of 2403-88-5.
Yin, Xueqian;Zhang, Jie;Xu, Jiazhuang;Tian, Meng;Li, Luying;Tan, Lin;Li, Zhongming research published 《 Fast-acting and highly rechargeable antibacterial composite nanofibrous membrane for protective applications》, the research content is summarized as follows. Bacterial infection has been globally recognized as one of the most prominent public health safety concerns, and the untreated surfaces are highly susceptible to the bacterial deposition and breeding without protective covers, thus the fabrication of potent membranes for shielding and combating bacteria is of vital importance. In this study, a powerful nanofibrous membrane on inactivating bacteria was fabricated based on a N-halamine polymeric system, which included a hydrophobic thermoplastic polyurethane (TPU) and a hydrophilic modified polyacrylic acid (PAA), and the fabricated membrane was called as TPM. According to the systematic investigations, TPM exhibited excellent antibacterial and antivirus activity, the min. inhibitory concentration to E. coli and S. aureus was 1.4 mg/mL. Upon contact, above 95% of both bacteria (≈106 CFU/mL) could be killed within 5 min, and the antiviral activity rate of TPM reached to above 99.92%. TPM also possessed a rapid chlorine loading capacity, which could completely load the active chlorine within 1 h, and the loading content of active chlorine rarely reduced even after five chlorination-quenching cycles, indicating excellent regenerative chlorination capacity. Addnl., the antibacterial mechanism in terms of macromol. release, morphol. damage and the reduction of respiratory chain dehydrogenase activity were studied. The resulting TPM with superior antibacterial performance can serve as a scalable biocidal layer for protective applications, and the facile synthesis of the TPM may also provide a strategy to develop protective materials in a sustainable, rechargeable, and structurally adaptive form.
Application In Synthesis of 2403-88-5, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., 2403-88-5.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem