Yin, Liang published the artcileDesign and development of novel thiazole-sulfonamide derivatives as a protective agent against diabetic cataract in Wistar rats via inhibition of aldose reductase, HPLC of Formula: 73874-95-0, the main research area is benzyl piperidinyl amino thiazolyl benzenesulfonamide preparation aldose reductase inhibition.
Then development of novel thiazole-sulfonamide hybrids I [R = H, 4-Cl, 3,4-di-Cl, etc.] as a potent inhibitor of ALR2 were intended. These mols. significantly inhibited the ALR2 level in the rat lenses homogenate, where the most potent compound I [R = 4-Cl] showed activity comparable to sorbinil as standard In Wistar rats, compound I [R = 4-Cl] improved the insulin level and body weight of the exptl. animal together with a reduction in the glucose output. Compound I [R = 4-Cl] showed a significant reduction in the expression of ALR2 in rat lenses in western blot anal.
Heterocyclic Communications published new progress about Aldose reductase inhibitors. 73874-95-0 belongs to class piperidines, name is tert-Butyl piperidin-4-ylcarbamate, and the molecular formula is C10H20N2O2, HPLC of Formula: 73874-95-0.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem