Biomimetic Oxidative Coupling Cyclization Enabling Rapid Construction of Isochromanoindolenines was written by Ye, Jinxiang;Lin, Yuqi;Liu, Qing;Xu, Dekang;Wu, Fan;Liu, Bin;Gao, Yu;Chen, Haijun. And the article was included in Organic Letters in 2018.Application In Synthesis of 1-Tosylpiperidin-4-one This article mentions the following:
Herein, we report a biomimetic oxidative coupling cyclization strategy for the highly efficient functionalization of tetrahydrocarbolines (THCs). This process enables rapid access to complex isochromanoindolenine scaffolds I (X = N, Y-R1 = CH2; Y = N, X-R2 = CH2; R1= R2= Ts, SO2Ph, Ac, etc.; R3 = H, 10-Cl, 9-F, 10-MeO, etc.) in moderate to excellent yields. The reaction proceeds smoothly and rapidly (complete within minutes) in an open flask. This operationally simple protocol is scalable and compatible with a wide range of functional groups. Late-stage functionalization of a pharmacol. relevant mol. is also demonstrated. In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9Application In Synthesis of 1-Tosylpiperidin-4-one).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Application In Synthesis of 1-Tosylpiperidin-4-one
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem