Yatam, Satayanarayana et al. published their research in Journal of Molecular Structure in 2018 | CAS: 41838-46-4

4-Amino-1-methylpiperidine (cas: 41838-46-4) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Application In Synthesis of 4-Amino-1-methylpiperidine

Focused library design and synthesis of 2-mercapto benzothiazole linked 1,2,4-oxadiazoles as COX-2/5-LOX inhibitors was written by Yatam, Satayanarayana;Gundla, Rambabu;Jadav, Surender Singh;Pedavenkatagari, Narayana reddy;Chimakurthy, Jithendra;Rani B, Namratha;Kedam, Thyagaraju. And the article was included in Journal of Molecular Structure in 2018.Application In Synthesis of 4-Amino-1-methylpiperidine This article mentions the following:

Mercapto benzothiazole linked 1,2,4-oxadiazole derivatives were designed as anti-inflammatory agents using bioisosteric approach and docking studies. The docking results clearly indicated that the compounds shown good docking interaction towards COX-2 enzyme. In silico drug-like properties were also calculated for the prepared compounds and exhibited significant H-bond acceptor ratio. All compounds were synthesized and biol. evaluated using in vitro COX-1, COX-2 and 5-LOX assays. Compound I and II (IC50 = 6.8 渭M and IC50 = 5.0 渭M) found to be potent, selective COX-2 inhibitors and display better anti-inflammatory activity than standard Ibuprofen. Compound III and IV found to be potent inhibitors against 5-LOX (IC50 = 5.1 渭M and IC50 = 5.5 渭M). The in vivo anti-inflammatory activity studies shown that the compounds II and I effectively reducing the paw edema volume at 3h and 5h than standard drug Ibuprofen. The DPPH radical scavenging activity provided anti-oxidant activity of compound IV (IC50 = 25.6 渭M) than reference standard Ascorbic acid. In the experiment, the researchers used many compounds, for example, 4-Amino-1-methylpiperidine (cas: 41838-46-4Application In Synthesis of 4-Amino-1-methylpiperidine).

4-Amino-1-methylpiperidine (cas: 41838-46-4) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Application In Synthesis of 4-Amino-1-methylpiperidine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem