Tertiary Amine Mediated Tandem Cross-Rauhut-Currier/Acetalization Reactions: Access to Functionalized Spiro-3,4-Dihydropyrans was written by Yao, Weijun;Wu, Yihua;Wang, Gang;Zhang, Yiping;Ma, Cheng. And the article was included in Angewandte Chemie, International Edition in 2009.Synthetic Route of C12H15NO3S This article mentions the following:
Spiro-3,4-dihydropyrans, e.g. I (R1 = Ph,, R2 = Me, Et; R1 = 4-FC6H4, 4-MeC6H4, R2 = Me; R1 = 3-O2NC6H4, 4-MeOC6H4, 2-furyl, N-tosylindol-3-yl, R2 = Et), were prepared by DBU-mediated cross-Rauhut-Currier/acetalization of cyclic β-haloenals, e.g. II, with β,γ-unsaturated α-ketoesters, e.g. (E)-R1CH:CHCOCO2R2, followed by oxidation In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9Synthetic Route of C12H15NO3S).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Synthetic Route of C12H15NO3S
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem