Structure-Activity Relationship Studies of Targeting Ligands against Breast Cancer Cells was written by Yao, Nianhuan;Xiao, Wenwu;Meza, Leah;Tseng, Harry;Chuck, Mathida;Lam, Kit S.. And the article was included in Journal of Medicinal Chemistry in 2009.Product Details of 86069-86-5 The following contents are mentioned in the article:
A series of LXY3 analogs was designed and synthesized. Their binding affinity was demonstrated using MDA-MB-231 breast cancer cells adherence inhibition assay. Further structure-activity relationship was obtained. One analog was discovered to have 3.5-fold increase of the binding affinity. Fluorescent microscopy and in vivo and ex vivo imaging studies demonstrated that it is an efficient in vivo targeting agent against α3 integrin of MDA-MB-231 breast tumor xenograft implant. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Product Details of 86069-86-5).
(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Product Details of 86069-86-5
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem