On March 12, 2021, Yang, Wanzhen; Tu, Jie; Ji, Changjin; Li, Zhuang; Han, Guiyan; Liu, Na; Li, Jian; Sheng, Chunquan published an article.Application In Synthesis of 4-(4-Chlorophenyl)piperidin-4-ol The title of the article was Discovery of Piperidol Derivatives for Combinational Treatment of Azole-Resistant Candidiasis. And the article contained the following:
Effective strategies are needed to deal with invasive fungal infections caused by drug-resistant fungi. Previously, we designed a series of antifungal benzocyclane derivatives based on the drug repurposing of haloperidol. Herein, further structural optimization and antifungal mechanism studies were performed, leading to the discovery of new piperidol derivative B2 (I) with improved synergistic antifungal potency, selectivity, and water solubility In particular, the combination of compound B2 and fluconazole showed potent in vitro and in vivo antifungal activity against azole-resistant Candida albicans. Compound B2 inhibited important virulence factors by regulating virulence-associated genes and improved the efficacy of fluconazole by down-regulating the CYP51-coding gene and efflux pump gene. Taken together, the piperidol derivative B2 represents a promising lead compound for the combinational treatment of azole-resistant candidiasis. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Application In Synthesis of 4-(4-Chlorophenyl)piperidin-4-ol
The Article related to antifungal candida drug resistance virulence factor candidiasis piperidol derivative, candida albicans, antifungal, drug resistance, piperidol derivatives, virulence factors and other aspects.Application In Synthesis of 4-(4-Chlorophenyl)piperidin-4-ol
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem