On June 24, 2022, Xu, Junyu; Li, Youbin; Zheng, Danyang; Wang, Xuesong; Wang, Yan; Tan, Yinfeng; Wang, Yong; Yang, Chenqi; Zhang, Yuchen; Guo, Tong published a patent.Related Products of 1216805-11-6 The title of the patent was Preparation method of N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)formamide derivative, and application thereof in preparation of drugs for treating and/or preventing hyperproliferative diseases. And the patent contained the following:
The title N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)formamide derivative is obtained by covalently linking T or Q and T with N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)formamide fragment, and has structural formulas as shown in claim 1, wherein Q is linking group, and is linear or branched alkylene chain composed of 1-10 CH2 or CH, and the linear or branched alkylene chain is linked with T via -NH-; and T is any one of fragments having structural formulas as shown in claim 1. The derivative has a specific structural formula as shown in claim 2, and is 2-(2,6-dioxopiperidin-3-yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-1,3-dioxoisoindoline-5-carboxamide. The derivative can effectively inhibit activity of human chronic myeloid leukemia cells and human gastrointestinal stromal tumor cells, and can be used in the preparation of drugs for treatment and/or prevention of hyperproliferative diseases, in particular for treatment of chronic myeloid leukemia and gastrointestinal stromal tumor. The experimental process involved the reaction of 2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindoline-5-carboxylic acid(cas: 1216805-11-6).Related Products of 1216805-11-6
The Article related to formamide pyrimidinylaminophenyl preparation hyperproliferative disease, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Related Products of 1216805-11-6
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem