Piperidine the name comes from the genus name Piper, which is the Latin word for pepper. 5382-16-1, formula is C5H11NO, Name is 4-Piperidinol. Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids, such as natural-occurring solenopsins. SDS of cas: 5382-16-1.
Wu, Qingmei;Zheng, Zhaopeng;Ye, Wenjun;Guo, Qian;Liao, Tianhui;Yang, Di;Zhao, Chunshen;Liao, Weike;Chai, Huifang;Zhou, Zhixu research published 《 Synthesis, crystal and molecular structure, vibrational spectroscopic, DFT and molecular docking of 4-(2-chlorobenzyl)-1-(4-hydroxy-3- ((4-hydroxypiperidin-1-yl) methyl-5-methoxyphenyl)-[1,2,4] triazolo [4,3-a] quinazolin-5(4H)-one》, the research content is summarized as follows. In current work, triazolo[4,3-a]quinazolinone I was synthesized. The structural properties of I were explored using spectroscopy (1H NMR, 13C NMR, MS and FT-IR) and X-ray crystallog. method. The single-crystal structure confirmed by X-ray diffraction was consistent with the mol. structure optimized by d. functional theory (DFT) calculation at B3LYP/6-311 G (2d, p) level of theory. The geometrical parameters, mol. electrostatic potential (MEP) and frontier MO (FMO) anal. were performed by DFT using the B3LYP/6-311 G (2d, p) method. Mol. docking may suggest a favorable interaction between I and SHP2 protein. The mol. dynamics (MD) simulation results shown that there are hydrogen bonds, electrostatic interactions and Pi interactions between compound I and SHP2 proteins. The inhibitory activity of I on SHP2 protein was better than the reference compound (SHP244).
5382-16-1, 4-Hydroxypiperidine is a molecule with a carbonyl group. It is the most active and selective CCR5 receptor antagonist that has been studied to date. 4-Hydroxypiperidine inhibits HIV infection by preventing the binding of HIV to its receptor on the surface of white blood cells, thereby preventing it from entering these cells. 4-Hydroxypiperidine also acts as an anti-inflammatory agent in chronic bronchitis patients, due to its ability to inhibit prostaglandin synthesis. The chemical ionization mass spectra of this molecule show peaks for methyl ethyl, malic acid, and hydroxyl groups. These properties make 4-hydroxypiperidine a useful candidate for drug development against inflammatory diseases and several cancers.
The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H receptor., SDS of cas: 5382-16-1
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem