On February 8, 2007, Williams, Theresa M. published a patent.Recommanded Product: Benzyl 7′-chloro-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxylate The title of the patent was Preparation of heterocyclic benzodiazepine derivatives as CGRP receptor antagonists. And the patent contained the following:
The title compounds with general formula I [wherein R2 = independently H, alkyl, cycloalkyl, aryl, heteroaryl, etc.; R7 = (un)substituted alkyl, alkenyl, alkynyl cycloalkyl, etc; D = N or C(R1), where R1 = independently (un)substituted alkyl, alkenyl, alkynyl, cycloalkyl, etc.; W = O, (un)substituted NH, or (un)substituted CH2; X = C or S; Y = O, N(CN), NC(=O)NH2, etc.; and Z = (un)substituted piperidinyl, aryl, or arylamino] or pharmaceutically acceptable salts and diastereomers thereof were prepared as antagonists of calcitonin gene-related peptide (CGRP) receptors for the treatment or prevention of diseases in which the CGRP is involved, such as migraine. For example, compound II was prepared in a multi-step synthesis. I showed antagonistic activity against CGRP receptor with IC50 values of about 50 μM in native receptor binding assay, native receptor functional assay, etc. The experimental process involved the reaction of Benzyl 7′-chloro-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxylate(cas: 883984-95-0).Recommanded Product: Benzyl 7′-chloro-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxylate
The Article related to preparation benzodiazepine piperidine benzene, cgrp receptor antagonist treatment human headache migraine, Heterocyclic Compounds (More Than One Hetero Atom): Diazepines and other aspects.Recommanded Product: Benzyl 7′-chloro-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxylate
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem