Thioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitors was written by Wiener, Danielle K.;Lee-Dutra, Alice;Bembenek, Scott;Nguyen, Steven;Thurmond, Robin L.;Sun, Siquan;Karlsson, Lars;Grice, Cheryl A.;Jones, Todd K.;Edwards, James P.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.SDS of cas: 58333-75-8 This article mentions the following:
A series of tetrahydropyrido-pyrazole cathepsin S (CatS) inhibitors with thioether acetamide functional groups were prepared with the goal of improving upon the cellular activity of amidoethylthioethers. This Letter describes altered amide connectivity, in conjunction with changes to other binding elements, resulting in improved potency, as well as increased knowledge of the relationship between this chemotype and human CatS activity. In the experiment, the researchers used many compounds, for example, 4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8SDS of cas: 58333-75-8).
4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.SDS of cas: 58333-75-8
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem