Recently I am researching about CARBONYL PROPARGYLATION; ASYMMETRIC AMINATION; DIENES; 1,3-ENYNES; 1,3-DIENES; ALDEHYDE; ALCOHOL; HYDROBORATION; ADDITIONS; KETONES, Saw an article supported by the National Science FoundationNational Science Foundation (NSF) [CHE-1800012]; Duke University; NIGMSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of General Medical Sciences (NIGMS) [T32GM007105]; Duke Chemistry Department; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of General Medical Sciences (NIGMS) [T32GM007105] Funding Source: NIH RePORTER. Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Adamson, NJ; Jeddi, H; Malcolmson, SJ. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane
In this study, we establish that conjugated enynes undergo selective 1,4-hydroamination under Pd catalysis to deliver chiral allenes with pendant allylic amines. Several primary and secondary aliphatic and aryl-substituted amines couple with a wide range of mono- and disubstituted enynes in a nonenantioselective reaction where DPEphos serves as the ligand for Pd. Benzophenone imine acts as an ammonia surrogate to afford primary amines in a two-step/one-pot process. Examination of chiral catalysts revealed a high degree of reversibility in the C-N bond formation that negatively impacted enantioselectivity. Consequently, an electron-poor ferrocenyl-PHOX ligand was developed to enable efficient and enantioselective enyne hydroamination.
Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. Welcome to talk about 177-11-7, If you have any questions, you can contact Adamson, NJ; Jeddi, H; Malcolmson, SJ or send Email.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem