Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. Recently I am researching about CYANOGEN-BROMIDE; N-CYANATION; ELECTROPHILIC CYANATION; TIEMANN REARRANGEMENT; PRACTICAL SYNTHESIS; BACE1 INHIBITOR; VERUBECESTAT; AMINATION, Saw an article supported by the . Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Kuhl, N; Raval, S; Cohen, RD. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane
An operationally simple oxidation cyanation method for the synthesis of cyanamides is described. The procedure utilizes inexpensive and commercially available N-chlorosuccinimide and Zn(CN)(2) as reagents to avoid direct handling of toxic cyanogen halides. It is demonstrated to be amenable for the cyanation of a variety of primary and secondary amines and aniline derivatives as well as a complex synthetic intermediate en route to verubecestat (MK-8931). Additionally, kinetic measurements and other control experiments are reported to shed light onto the mechanism of this cyanation reaction.
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Reference：
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