Lai, Zeng-Wei; Li, Chunhong; Liu, Jun; Kong, Lingyi; Wen, Xiaoan; Sun, Hongbin published an article about the compound: (S)-Piperidin-3-amine dihydrochloride( cas:334618-07-4,SMILESS:Cl.Cl.N[C@H]1CCCNC1 ).COA of Formula: C5H14Cl2N2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:334618-07-4) through the article.
Highly potent DPP-4 inhibitors have been identified by hybrid compound design based on linagliptin and alogliptin. The most promising compound I (IC50 = 0.31 nM) exhibited 8.5-fold and 2.5-fold more potent activity than that of alogliptin (IC50 = 2.63 nM) and linagliptin (IC50 = 0.77 nM), resp. Compound I had a good inhibition selectivity for DPP-4 over DPP-8/9 and thus was selected for further biol. evaluation, including oral glucose tolerance, plasma DPP-4 inhibitory activity, pharmacokinetic profile, acute toxicity and hERG inhibition. The assay results showed that I displayed significant in vivo glucose-lowering effect and low risk of toxicity. Further studies are expected to confirm I as a potential drug candidate for the treatment of type 2 diabetes.
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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem