Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Recommanded Product: 5,6-Dimethoxy-2-(4-piperidinylmethyl)-1-indanone hydrochloride, 120013-39-0, Name is 5,6-Dimethoxy-2-(4-piperidinylmethyl)-1-indanone hydrochloride, molecular formula is C17H24ClNO3, belongs to piperidines compound. In a document, author is Matous, Petr, introduce the new discover.
Nucleophile-assisted cyclization of beta-propargylamino acrylic compounds catalyzed by gold(I): a rapid construction of multisubstituted tetrahydropyridines and their fused derivatives
Au(I)-catalyzed cyclization of beta-propargylamino acrylic derivatives 1, carried out in the presence of methanol, afforded tetrahydropyridines 3 in high isolated yields. An intramolecular version, using substrates with pending OH, NHBoc and 3-MeOC6H4 groups as internal O-, N-, and C-nucleophiles, yielded the orthofused cyclic derivatives, namely furo[2,3-b]pyridine derivative 14, pyrrolo[2,3-b]pyridine 18, and an unusual chromeno[3,4-c]pyridine 22 with a new quaternary carbon center. Synthetic utilization of the tetrahydropyridines 3 has been demonstrated by their conversion into substances with privileged pharmacophore scaffold. Thus, four 4-aryl piperidine derivatives 23a,b,f,g were obtained on catalytic hydrogenation of the representative 4-aryl tetrahydropyridines 3a,b,f,g; furthermore, the Diels-Alder cycloaddition of dimethyl acetylene dicarboxylate (DMAD) to dienes 3r-3u, possessing a masked dendralene framework, afforded tetrahydroisoquinolines 25r-25u that can be aromatized to produce polysubstituted isoquinolines, as demonstrated by the conversion of 25r into 27r. These domino transformations thus offer numerous variations of this methodology and reveal its potential for synthetic applications.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 120013-39-0. Recommanded Product: 5,6-Dimethoxy-2-(4-piperidinylmethyl)-1-indanone hydrochloride.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem