Reference of 34737-89-8, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 34737-89-8, Name is 1-Benzyl-3-methylpiperidin-4-one, SMILES is O=C1C(C)CN(CC2=CC=CC=C2)CC1, belongs to piperidines compound. In a article, author is Dileep, K., V, introduce new discover of the category.
Piperidine-4-carboxamide as a new scaffold for designing secretory glutaminyl cyclase inhibitors
Alzheimer’s disease (AD), a common chronic neurodegenerative disease, has become a major public health concern. Despite years of research, therapeutics for AD are limited. Overexpression of secretory glutaminyl cyclase (sQC) in AD brain leads to the formation of a highly neurotoxic pyroglutamate variant of amyloid beta, pGluAp, which acts as a potential seed for the aggregation of full length A beta. Preventing the formation of pGlu-A beta through inhibition of sQC has become an attractive disease-modifying therapy in AD. In this current study, through a pharmacophore assisted high throughput virtual screening, we report a novel sQC inhibitor (Cpd-41) with a piperidine-4-carboxamide moiety (IC50 = 34 mu M). Systematic molecular docking, MD simulations and X-ray crystallographic analysis provided atomistic details of the binding of Cpd-41 in the active site of sQC. The unique mode of binding and moderate toxicity of Cpd-41 make this molecule an attractive candidate for designing high affinity sQC inhibitors. (C) 2020 Elsevier B.V. All rights reserved.
Reference of 34737-89-8, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 34737-89-8.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem