Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Recommanded Product: 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, 401566-79-8, Name is 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, molecular formula is C14H18N4, belongs to piperidines compound. In a document, author is Rong, Rui-Xue, introduce the new discover.
Lysosomes-targeting imaging and anticancer properties of novel bis-naphthalimide derivatives
A series of novel N, N-bis(3-aminopropyl) methylamine bridged bis-naphthalimide derivatives NI1-NI8 containing saturated nitrogenous heterocycles were designed and synthesized, their cytotoxic activities against Hela, MCF-7, A549 and MGC-803 cells were investigated, Compounds NI1-NI4 modified with piperidine and piperazine exhibited good and selective cytotoxic activity, for instance, compounds NI1 and NI4 showed potent cytotoxic activity against Hela cells and MGC-803 cells with the IC50 values of 2.89, 060, 2.73 and 1.60 mu M, respectively, better than the control drug (Amonafide). However, compounds NI5-NI8 conjugated with pyrrole derivatives showed weak cytotoxic activities against the all tested cell lines. Furthermore, their DNA binding properties, fluorescence imaging and cell cycle were investigated. Interestingly, compounds NI1 and NI4 showed fluorescence enhancement because of the strong binding with Ct-DNA, and exhibited fluorescence imaging with Hela cells on the lysosomes. (C) 2018 Elsevier Ltd. All rights reserved.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 401566-79-8. Recommanded Product: 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem