Electric Literature of C10H19NO3In 2021 ,《Discovery and Optimization of a Novel 2H-Pyrazolo[3,4-d]pyrimidine Derivative as a Potent Irreversible Pan-Fibroblast Growth Factor Receptor Inhibitor》 appeared in Journal of Medicinal Chemistry. The author of the article were Wei, Yujiao; Tang, Yanting; Zhou, Yunyun; Yang, Yuyu; Cui, Yetong; Wang, Xuan; Wang, Yubo; Liu, Yulin; Liu, Ning; Wang, Qianqian; Li, Chong; Ruan, Hao; Zhou, Honggang; Wei, Mingming; Yang, Guang; Yang, Cheng. The article conveys some information:
Fibroblast growth factor receptors (FGFRs) have become promising therapeutic targets in various types of cancers. In fact, several selective irreversible inhibitors capable of covalently reacting with the conserved cysteine of FGFRs are currently being evaluated in clin. trials. In this article, we optimized and discovered a novel lead compound 36 with remarkable inhibitory effects against FGFR (1-3), which is a derivative of 2H-pyrazolo[3,4-d]pyrimidine. The irreversible binding to FGFRs was characterized by LC-MS. This compound has been shown to exhibit significant anti-proliferation effects against NCI-H1581 and SNU-16 cancer cell lines both in vitro and in vivo. Compound 36 has also demonstrated a low toxicity profile and adequate pharmacokinetic properties and is currently under validation as a potential drug candidate.tert-Butyl 4-hydroxypiperidine-1-carboxylate(cas: 109384-19-2Electric Literature of C10H19NO3) was used in this study.
tert-Butyl 4-hydroxypiperidine-1-carboxylate(cas:109384-19-2) is a 4-hydroxypyridine with a boc protecting group used in the preparation of neurologically active agents and other pharmaceutical compounds.Electric Literature of C10H19NO3
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem