1-(1,3-Benzodioxol-5-ylmethyl)-3-[4-(1H-imidazol-1-yl)phenoxy]-piperidine analogs as potent and selective inhibitors of nitric oxide formation was written by Wei, Robert G.;Adler, Marc;Davey, David;Ho, Elena;Mohan, Raju;Polokoff, Mark;Tseng, Jih-Lie;Whitlow, Marc;Xu, Wei;Yuan, Shendong;Phillips, Gary. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Formula: C12H18ClNO This article mentions the following:
A new series of 1-(1,3-benzodioxol-5-ylmethyl)-3-[4-(1H-Imidazol-1-yl)phenoxy]-piperidine analogs were designed and identified as potent and selective inhibitors of NO formation based both on the crystal structure of a murine iNOS Δ114 monomer domain/ inhibitor complex and inhibition of the NO formation in human A172 cell assays. Compound 12S showed high potency and high iNOS selectivity vs. nNOS and eNOS. In the experiment, the researchers used many compounds, for example, 1-Benzyl-3-piperidinol hydrochloride (cas: 105973-51-1Formula: C12H18ClNO).
1-Benzyl-3-piperidinol hydrochloride (cas: 105973-51-1) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Formula: C12H18ClNO
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem