Wang, Zemin published the artcileDearomatization-Rearomatization Strategy for Reductive Cross-Coupling of Indoles with Ketones in Water, Application In Synthesis of 170364-89-3, the publication is Organic Letters (2019), 21(7), 2302-2306, database is CAplus and MEDLINE.
N-Alkylation of indoles is one of the important pathways for the construction of various biol. active indole mols. Using ketones as N-alkylation reagent for indoles was a great challenge not only because of the competing alkylation reaction of C-3 position but also because of the poor nucleophilicity of the nitrogen atom of indole, in addition to the steric hindrance and lower electrophilicity of the ketones. A dearomatization-rearomatization strategy was developed for reductive cross-coupling of indoles with ketones in water. Various functional groups and other heterocyclic compounds are tolerated.
Organic Letters published new progress about 170364-89-3. 170364-89-3 belongs to piperidines, auxiliary class Indole,Piperidine,Amide, name is tert-Butyl 4-(1H-indol-1-yl)piperidine-1-carboxylate, and the molecular formula is C18H10, Application In Synthesis of 170364-89-3.
Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem