Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists was written by Wang, Xueqing;Bhatia, Pramila A.;Daanen, Jerome F.;Latsaw, Steve P.;Rohde, Jeffrey;Kolasa, Teodozyi;Hakeem, Ahmed A.;Matulenko, Mark A.;Nakane, Masaki;Uchic, Marie E.;Miller, Loan N.;Chang, Renjie;Moreland, Robert B.;Brioni, Jorge D.;Stewart, Andrew O.. And the article was included in Bioorganic & Medicinal Chemistry in 2005.Electric Literature of C10H14N2 The following contents are mentioned in the article:
A series of 3-aryl piperidine analogs with 2-piperidinoalkylamino or 2-piperidinoalkyloxy fused bicyclic rings were prepared and found to be potent and efficacious human dopamine D4 agonists. The synthesis and structure-activity relationship (SAR) studies that led to the identification of these compounds are discussed. This study involved multiple reactions and reactants, such as 3-(Piperidin-3-yl)pyridine (cas: 31251-28-2Electric Literature of C10H14N2).
3-(Piperidin-3-yl)pyridine (cas: 31251-28-2) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Electric Literature of C10H14N2
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem