Simultaneous determination of multi-class antibiotics and steroid hormones drugs in livestock and poultry faeces using liquid chromatography-quadrupole time-of-flight mass spectrometry was written by Wang, Kewen;Wang, Xue;Xu, Zhenzhen;Yang, Shuming. And the article was included in Food Additives & Contaminants, Part A in 2020.Formula: C19H20F3N3O3 This article mentions the following:
A method for simultaneous determination of multi-class antibiotics and steroid hormone anal. in faeces of livestock and poultry was developed using liquid chromatog.-quadrupole time-of-flight mass spectrometry (LC-QTOF MS). An inhouse database was built for 156 detected drugs using Personal Compound Database Library software (PCDL) including compound name, monoisotopic mass, chem. formula, RT, chem. structure and three CID MS/MS spectra. The linearity result showed that all the drugs exhibited good linearity with determination coefficients (R2) higher than 0.99. The drug recoveries and their RSDs for all three faeces samples (pig, cattle and chicken) were tested and 81, 96 and 92 drugs were chosen for anal. in pig, cattle and chicken faeces, resp. Further validation showed that 73 veterinary drugs in all three kinds of faeces samples can be quantified in one anal. run. This work shows that qual. and quant. anal. using LC-QTOF MS represents a simple, sensitive, low-cost and high-throughput methodol. in routine laboratory analyses. In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (cas: 113617-63-3Formula: C19H20F3N3O3).
1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (cas: 113617-63-3) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Formula: C19H20F3N3O3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics