Alcohols as Alkylating Agents: Photoredox-Catalyzed Conjugate Alkylation via In Situ Deoxygenation was written by Wang, Johnny Z.;Sakai, Holt A.;MacMillan, David W. C.. And the article was included in Angewandte Chemie, International Edition in 2022.Recommanded Product: 1-Boc-4-Hydroxy-4-methylpiperidine This article mentions the following:
Herein, an operationally convenient, N-heterocyclic carbene (NHC)-mediated deoxygenative Giese-type addition of alc.-derived alkyl radicals to electron-deficient alkenes under mild photocatalytic conditions was described. The fragment coupling accommodated a broad range of primary, secondary, and tertiary alc. partners, as well as structurally varied Michael acceptors containing traditionally reactive sites, such as electrophilic or oxidizable moieties. The late-stage diversification of densely functionalized mol. architectures, including drugs and biomols. was demonstrated, and this protocol with metallaphotoredox cross-coupling for step-economic access to sp3-rich complexity was telescoped. In the experiment, the researchers used many compounds, for example, 1-Boc-4-Hydroxy-4-methylpiperidine (cas: 406235-30-1Recommanded Product: 1-Boc-4-Hydroxy-4-methylpiperidine).
1-Boc-4-Hydroxy-4-methylpiperidine (cas: 406235-30-1) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Recommanded Product: 1-Boc-4-Hydroxy-4-methylpiperidine
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem