《Design, synthesis, and structure activity relationship (SAR) studies of novel imidazo[1,2-a]pyridine derivatives as Nek2 inhibitors》 was written by Wang, Haili; Chen, Yunzhong; Gu, Xiaofan; Xi, Jianbei; Ren, Ziwei; Wang, Shuting; Duan, Yanhong; Li, Hongyu; Zhu, Tong; Du, Yijie; Zhang, Xiongwen; Ma, Mingliang. Formula: C10H19NO3 And the article was included in Bioorganic & Medicinal Chemistry in 2020. The article conveys some information:
Herein, a series of imidazo[1,2-a]pyridines, e.g., I, Nek2 inhibitors were designed, synthesized and their biol. activities were investigated. Besides, structure activity relationship anal. of these compounds were performed in the MGC-803 cell. The screening results are promising, and tert-Bu 3-((4-(3-(5-carbamoyl-4-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophen-2-yl) imidazo[1,2-a] pyridine-7-yl)-1H-pyrazol-1-yl)methyl)azetidine-1-carboxylate showed good proliferation inhibitory activity with an IC50 of 38 nM. The results would be helpful to design and develop more effective Nek2 inhibitors for the treatment of gastric cancer. In addition to this study using tert-Butyl 4-hydroxypiperidine-1-carboxylate, there are many other studies that have used tert-Butyl 4-hydroxypiperidine-1-carboxylate(cas: 109384-19-2Formula: C10H19NO3) was used in this study.
tert-Butyl 4-hydroxypiperidine-1-carboxylate(cas:109384-19-2) is a 4-hydroxypyridine with a boc protecting group used in the preparation of neurologically active agents and other pharmaceutical compounds.Formula: C10H19NO3
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem