In silico plasma protein binding studies of selected group of drugs using TLC and HPLC retention data was written by Wanat, Karolina;Zydek, Grazyna;Hekner, Adam;Brzezinska, Elzbieta. And the article was included in Pharmaceuticals in 2021.Name: 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid The following contents are mentioned in the article:
Plasma protein binding is an important determinant of the pharmacokinetic properties of chem. compounds in living organisms. The aim of the present study was to determine the index of protein binding affinity based on chromatog. experiments The question is which chromatog. environment will best mimic the drug-protein binding conditions. Retention data from normal phase thin-layer liquid chromatog. (NP TLC), reversed phase (RP) TLC and HPLC chromatog. experiments with 129 active pharmaceutical ingredients (APIs) were collected. The stationary phase of the TLC plates was modified with protein and the HPLC column was filled with immobilized human serum albumin. In both chromatog. methods, the mobile phase was based on a buffer with a pH of 7.4 to mimic physiol. conditions. Chemometric analyses were performed to compare multiple linear regression models (MLRs) with retention data, using protein binding values as the dependent variable. In the course of the anal., APIs were divided into acidic, basic and neutral groups, and sep. models were created for each group. The MLR models had a coefficient of determination between 0.73 and 0.91, with the highest values from NP TLC data. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Name: 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid).
2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Name: 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem