Vuong, Wayne’s team published research in Organic Letters in 21 | CAS: 826-36-8

Organic Letters published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C19H21N3O3S, Application of 2,2,6,6-Tetramethylpiperidin-4-one.

Vuong, Wayne published the artcileSynthesis of Chiral Spin-Labeled Amino Acids, Application of 2,2,6,6-Tetramethylpiperidin-4-one, the publication is Organic Letters (2019), 21(24), 10149-10153, database is CAplus and MEDLINE.

Spin-labeled amino acids (SLAAs) are often used to determine intermol. distances and conformations in proteins via double electron-electron resonance. Currently available SLAAs can be difficult to incorporate selectively and have little resemblance to natural side chains in proteins. Enantioselective synthesis of three spin-labeled L-amino acids is described, starting from readily available 2,2,6,6-tetramethyl-4-piperidinone. These SLAAs better replicate canonical residues in proteins and aim for biol. incorporation via genetic incorporation or solid-phase peptide synthesis.

Organic Letters published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C19H21N3O3S, Application of 2,2,6,6-Tetramethylpiperidin-4-one.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem