Piperidine was first reported in 1850 by the Scottish chemist Thomas Anderson and again, independently, in 1852 by the French chemist 5382-16-1, formula is C5H11NO, Name is 4-Piperidinol. Auguste Cahours, who named it. Both of them obtained piperidine by reacting piperine with nitric acid. Recommanded Product: 4-Piperidinol.
Voloshkin, Vladislav A.;Kotovshchikov, Yury N.;Latyshev, Gennadij V.;Lukashev, Nikolay V.;Beletskaya, Irina P. research published 《 Annulation-Triggered Denitrogenative Transformations of 2-(5-Iodo-1,2,3-triazolyl)benzoic Acids》, the research content is summarized as follows. The ability of [1,2,3]triazolobenzoxazinones I (R1 = H, 7-Br, 9-Me; R2 = n-Bu, Ph, cyclohexylmethyl, 3-methylbutyl) to act as a source of “hidden” diazo group was discovered. These diazo precursors can be easily prepared by the intramol. cyclization of 2-(5-iodo-1,2,3-triazolyl)benzoic acids II (R3 = H, 5-Br, 3-Me, etc.). The Cu-catalyzed capture of the hidden diazo group allows for further functionalization through the denitrogenative pathway. The transformations proceed via the formation of either diazoimine or diazoamide intermediates. Novel routes to various anthranilamides R3NHC(O)CH(R2)R4 (R3 = 4,5-dimethoxy-2-[(pyrrolidin-1-yl)carbonyl]benzen-1-yl, 2-[(morpholin-4-yl)carbonyl]benzen-1-yl, 4-bromo-2-[(pyrrolidin-1-yl)carbonyl]benzen-1-yl, etc.; R4 = pyrrolidin-1-yl, (5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl, morpholin-4-yl, etc.) as well as thiolated benzoxazinones III (R5 = 5-methyl-1,3,4-thiadiazol-2-yl, 1,3-benzoxazol-2-yl, 1-methyl-1H-1,2,3,4-tetrazol-5-yl, etc.) were developed using the one-pot cyclization/diazo capture procedure.
5382-16-1, 4-Hydroxypiperidine is a molecule with a carbonyl group. It is the most active and selective CCR5 receptor antagonist that has been studied to date. 4-Hydroxypiperidine inhibits HIV infection by preventing the binding of HIV to its receptor on the surface of white blood cells, thereby preventing it from entering these cells. 4-Hydroxypiperidine also acts as an anti-inflammatory agent in chronic bronchitis patients, due to its ability to inhibit prostaglandin synthesis. The chemical ionization mass spectra of this molecule show peaks for methyl ethyl, malic acid, and hydroxyl groups. These properties make 4-hydroxypiperidine a useful candidate for drug development against inflammatory diseases and several cancers.
The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H receptor., Recommanded Product: 4-Piperidinol
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem