Vilums, Maris et al. published their research in ChemMedChem in 2012 | CAS: 25519-80-6

Phenyl(piperidin-4-yl)methanone hydrochloride (cas: 25519-80-6) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Synthetic Route of C12H16ClNO

Understanding of Molecular Substructures that Contribute to hERG K+ Channel Blockade: Synthesis and Biological Evaluation of E-4031 Analogues was written by Vilums, Maris;Overman, Jeroen;Klaasse, Elisabeth;Scheel, Olaf;Brussee, Johannes;Ijzerman, Adriaan P.. And the article was included in ChemMedChem in 2012.Synthetic Route of C12H16ClNO This article mentions the following:

Cardiotoxicity is a common side effect of a large variety of drugs that is often caused by off-target human ether-a-go-go-related gene (hERG) potassium channel blockade. In this study, we designed and synthesized a series of derivatives of the class III antiarrhythmic agent E-4031. These compounds where evaluated in a radioligand binding assay and automated patch clamp assay to establish structure-activity relationships (SAR) for their inhibition of the hERG K+ channel. Structural modifications of E-4031 were made by altering the peripheral aromatic moieties with a series of distinct substituents. Addnl., we synthesized several derivatives with a quaternary nitrogen and modified the center of the mol. by introduction of an addnl. nitrogen and deletion of the carbonyl oxygen. Some modifications caused a great increase in affinity for the hERG K+ channel, while other seemingly minor changes led to a strongly diminished affinity. Structures with quaternary amines carrying an addnl. aromatic moiety were found to be highly active in radioligand binding assay. A decrease in affinity was achieved by introducing an amide functionality in the central scaffold without directly interfering with the pKa of the essential basic amine. The knowledge gained from this study could be used in early stages of drug discovery and drug development to avoid or circumvent hERG K+ channel blockade, thereby reducing the risk of cardiotoxicity, related arrhythmias and sudden death. In the experiment, the researchers used many compounds, for example, Phenyl(piperidin-4-yl)methanone hydrochloride (cas: 25519-80-6Synthetic Route of C12H16ClNO).

Phenyl(piperidin-4-yl)methanone hydrochloride (cas: 25519-80-6) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Synthetic Route of C12H16ClNO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem