In 2022,Villegas, Alondra; Satheeshkumar, Rajendran; Ballesteros-Casallas, Andres; Paulino, Margot; Castro, Alejandro; Espinosa-Bustos, Christian; Salas, Cristian O. published an article in Journal of Heterocyclic Chemistry. The title of the article was 《Convergent synthesis, drug target prediction, and docking studies of new 2,6,9-trisubstituted purine derivatives》.Application of 87120-72-7 The author mentioned the following in the article:
A set of new 2,6,9-trisubstituted purine derivatives were designed and synthesized from 6-chloro-2-fluoro-9-alkyl-9H-purine as the key starting material. These purines were synthesized via a multistep protocol and finally subjected to SNAr with various aminopiperidinyl salts. The structures of these compounds were established by substantiating them through spectral techniques like FT-IR, 1H-NMR, 13C-NMR, and 19F-NMR. In addition, for two purine derivatives, a reverse screening strategy based on ligand similarity (PharmMapper web server) resulted in a set of predicted protein target candidates. Interestingly, for both purines, the main potential target candidates belonged to key proteins involved within signaling pathways that are related to proliferation or survival of cancer cells. These proteins correspond mainly to enzymes and specifically kinases. To check if our purines could be ligands for two kinases involved in cancer, docking studies were performed. The results indicated that these purines fitted in the same cavity of crystalized inhibitors. Therefore, in this work we are developed new purine derivatives that could be good inhibitors of some kinases. In the experimental materials used by the author, we found tert-Butyl 4-aminopiperidine-1-carboxylate(cas: 87120-72-7Application of 87120-72-7)
tert-Butyl 4-aminopiperidine-1-carboxylate(cas: 87120-72-7) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Application of 87120-72-7
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem