Vendrell, Marc published the artcileIndoloquinolizidine-peptide hybrids as multiple agonists for D1 and D2 dopamine receptors, Formula: C21H21NO4, the main research area is indoloquinolizidine peptide hybrid preparation dopamine receptor agonist structure activity; solid phase synthesis peptide combinatorial library indoloquinolizidine drug design; radioligand binding brain striatum membrane intracellular cAMP production assay; peptide indoloquinolizidine acid asym synthesis tryptophyl reduction hydrogenation hydrolysis.
Multiple-specificity ligands are considered promising pharmacol. tools that may show higher efficacy in the treatment of diseases for which the modulation of a single target is therapeutically inadequate. We prepared a set of novel ligands for D1 and D2 dopamine receptors by combining two indolo[2,3-a]quinolizidine scaffolds with various tripeptide moieties. The binding and functional properties of these mols. were determined by radioligand binding studies in brain striatum membranes and by intracellular cAMP production assays in cells expressing different dopamine receptor subtypes. Some indoloquinolizidine-peptide hybrids, mainly with the trans configuration, showed dual agonist activity at both D1 and D2 dopamine receptors and may therefore be useful for testing the therapeutic potential of multivalent drugs on these targets.
ChemMedChem published new progress about Animal cell line. 158922-07-7 belongs to class piperidines, name is 1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-3-carboxylic acid, and the molecular formula is C21H21NO4, Formula: C21H21NO4.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem