2-Phenylpyrroles as conformationally restricted benzamide analogs. A new class of potential antipsychotics. 2 was written by Van Wijngaarden, Ineke;Kruse, Chris G.;Van der Heyden, Jan A. M.;Tulp, Martin T. M.. And the article was included in Journal of Medicinal Chemistry in 1988.Synthetic Route of C12H17NO This article mentions the following:
A series of 2-phenylpyrrole Mannich bases I (R = H, 4-F, 4-CF3, 4-CHMe2, 3-Cl, 2-OMe, 2,6-F2; R1 = H, Me, Ph, CF2CF2CF3, CH2CH2OH) and II (R2 = H, F; X = NC6H4CF3-3, NC6H4F-4, CHPh, CHC6H4OMe-2, etc.) was synthesized and screened in pharmacol. models for antipsychotic activity and extrapyramidal effects. Structure modifications of I (R1 = 4-F, R2 = H), the prototype of a new class of sodium-independent atypical dopamine D-2 antagonists, resultes in II (R2 = F, X = imino-7-benzofuranyl) (III), which was an even more potent and selective D-2 antagonist than the parent compound The excellent oral activity in the apomorphine-induced climbing behavior and the conditioned avoidance response tests and the absence of catalepsy make III particularly promising as a potential antipsychotic with a low propensity to induce acute extrapyramidal side effects. In the experiment, the researchers used many compounds, for example, 4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8Synthetic Route of C12H17NO).
4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Synthetic Route of C12H17NO
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem